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Details on Person UniProt:P22102 GART
| Class:Id | ReferenceGeneProduct:62499 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-1010 added on Fri February 6 2015;initiator methionine:1 for 62499 removed on Fri Nov 03 2023;initiator methionine: for 62499 added on Fri Nov 03 2023;initiator methionine: for 62499 removed on Fri Aug 15 2025;initiator methionine:1 for 62499 added on Fri Aug 15 2025 |
| _displayName | UniProt:P22102 GART |
| _timestamp | 2025-08-15 22:03:31 |
| chain | initiator methionine:1 chain:2-1010 |
| checksum | 9A4213F746EB17A2 |
| comment | FUNCTION Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway.CATALYTIC ACTIVITY 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)CATALYTIC ACTIVITY N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)CATALYTIC ACTIVITY 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)COFACTOR Binds 1 magnesium or manganese ion per subunit.PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.SUBUNIT Homodimer.ALTERNATIVE PRODUCTS The N-terminal ATP-grasp domain carries the phosphoribosylamine--glycine ligase activity.DOMAIN The central AIRS domain carries the phosphoribosylformylglycinamidine cyclo-ligase activity.DOMAIN The C-terminal GART domain carries the phosphoribosylglycinamide formyltransferase activity.SIMILARITY In the N-terminal section; belongs to the GARS family.SIMILARITY In the central section; belongs to the AIR synthase family.SIMILARITY In the C-terminal section; belongs to the GART family. |
| description | recommendedName: fullName evidence="19"Trifunctional purine biosynthetic protein adenosine-3 domain recommendedName: fullName evidence="19"Phosphoribosylamine--glycine ligase ecNumber evidence="18 19"6.3.4.13 alternativeName: Glycinamide ribonucleotide synthetase shortName evidence="13"GARS alternativeName: fullName evidence="13"Phosphoribosylglycinamide synthetase /domain domain recommendedName: fullName evidence="19"Phosphoribosylformylglycinamidine cyclo-ligase ecNumber evidence="18 19"6.3.3.1 alternativeName: AIR synthase shortName evidence="13"AIRS alternativeName: Phosphoribosyl-aminoimidazole synthetase /domain domain recommendedName: fullName evidence="13"Phosphoribosylglycinamide formyltransferase ecNumber evidence="5 6 18 19"2.1.2.2 alternativeName: 5'-phosphoribosylglycinamide transformylase alternativeName: fullName evidence="11"GAR transformylase shortName evidence="13"GART /domain |
| geneName | GART PGFT PRGS |
| identifier | P22102 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Ligase Magnesium Manganese Metal-binding Multifunctional enzyme Nucleotide-binding Phosphoprotein Proteomics identification Purine biosynthesis Reference proteome Transferase |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GART |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8960134] ENSEMBL:ENSG00000159131 GART [Homo sapiens] |
| secondaryIdentifier | PUR2_HUMAN A8K945 A8KA32 D3DSF3 D3DSF4 O14659 Q52M77 |
| sequenceLength | 1010 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152642] UniProt:P22102-2 GART [Homo sapiens] [ReferenceIsoform:403320] UniProt:P22102-1 GART [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:62498] GART [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8960503] GART [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P22102 GART (62499)
