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Details on Person UniProt:Q12923 PTPN13
| Class:Id | ReferenceGeneProduct:62443 |
|---|---|
| _chainChangeLog | chain:1-2485 added on Sat February 7 2015 |
| _displayName | UniProt:Q12923 PTPN13 |
| _timestamp | 2025-02-21 19:11:24 |
| chain | chain:1-2485 |
| checksum | 8D1B31597C66962B |
| comment | FUNCTION Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateSUBUNIT Interacts (via the first PDZ domain) with PLEKHA1 and PLEKHA2 (PubMed:14516276). Interacts (via the second PDZ domain) with TNFRSF6 (Fas receptor) (via C-terminus) (PubMed:10704206). Interacts (via the second PDZ domain) with TRIP6 (via the third LIM domain and C-terminus) (PubMed:10400701, PubMed:10826496). Interacts (via the third PDZ domain) with NGFR (via C-terminal SVP motif) and PKN2 (via C-terminus) (PubMed:10544233, PubMed:11356191). Interacts (via the second or fourth PDZ domains) with PDLIM4 (via C-terminus only or via combined C-terminus and LIM domain, but not LIM domain only). Found in a complex with PDLIM4 and TRIP6 (By similarity). Interacts with PDLIM4; this interaction results in dephosphorylation of SRC 'Tyr-419' by this protein leading to its inactivation (PubMed:19307596). Interacts with BRD7 (By similarity). Interacts with RAPGEF6 (PubMed:12095257). Interacts with ARHGAP29 (PubMed:9305890). Interacts with PIK3R2; dephosphorylates PIK3R2 (PubMed:23604317). Interacts with FBXL2 (PubMed:23604317). Interacts (via the FERM domain) with ENTR1 (PubMed:23108400). Found in a complex with ENTR1, PTPN13 and GIT1 (PubMed:23108400).INTERACTION Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191).ALTERNATIVE PRODUCTS Expressed in keratinocytes (at protein level) (PubMed:29043977). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.MISCELLANEOUS May be due to a competing donor splice site.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| description | recommendedName: Tyrosine-protein phosphatase non-receptor type 13 ecNumber evidence="17 18"3.1.3.48 alternativeName: Fas-associated protein-tyrosine phosphatase 1 shortName: FAP-1 alternativeName: PTP-BAS alternativeName: Protein-tyrosine phosphatase 1E shortName: PTP-E1 shortName: hPTPE1 alternativeName: Protein-tyrosine phosphatase PTPL1 |
| geneName | PTPN13 PNP1 PTP1E PTPL1 |
| identifier | Q12923 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell projection Coiled coil Cytoplasm Cytoskeleton Hydrolase Nucleus Phosphoprotein Protein phosphatase Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PTPN13 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962162] ENSEMBL:ENSG00000163629 PTPN13 [Homo sapiens] |
| secondaryIdentifier | PTN13_HUMAN B2RTR0 Q15159 Q15263 Q15264 Q15265 Q15674 Q16826 Q8IWH7 Q9NYN9 Q9UDA8 |
| sequenceLength | 2485 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152575] UniProt:Q12923-2 PTPN13 [Homo sapiens] [ReferenceIsoform:152576] UniProt:Q12923-3 PTPN13 [Homo sapiens] [ReferenceIsoform:152577] UniProt:Q12923-4 PTPN13 [Homo sapiens] [ReferenceIsoform:405535] UniProt:Q12923-1 PTPN13 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8870318] PTPN13 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9008915] PTPN13 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q12923 PTPN13 (62443)
