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Details on Person UniProt:Q16647 PTGIS
| Class:Id | ReferenceGeneProduct:62411 |
|---|---|
| _chainChangeLog | chain:1-500 added on Sat February 7 2015 |
| _displayName | UniProt:Q16647 PTGIS |
| _timestamp | 2024-11-03 19:53:26 |
| chain | chain:1-500 |
| checksum | 39595442BFC0B625 |
| comment | FUNCTION Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323).CATALYTIC ACTIVITY prostaglandin H2 = prostaglandin I2CATALYTIC ACTIVITY a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2OCATALYTIC ACTIVITY (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2OCATALYTIC ACTIVITY (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2OCOFACTOR Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the cytochrome P450 family.ONLINE INFORMATION CYP8A1 alleles |
| description | recommendedName: Prostacyclin synthase ecNumber evidence="6 9 10"5.3.99.4 alternativeName: fullName evidence="12"Hydroperoxy icosatetraenoate dehydratase ecNumber evidence="8"4.2.1.152 alternativeName: Prostaglandin I2 synthase |
| geneName | PTGIS CYP8 CYP8A1 |
| identifier | Q16647 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Heme Iron Isomerase Lipid biosynthesis Lipid metabolism Lyase Membrane Metal-binding Prostaglandin biosynthesis Prostaglandin metabolism Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PTGIS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958219] ENSEMBL:ENSG00000124212 PTGIS [Homo sapiens] |
| secondaryIdentifier | PTGIS_HUMAN Q3MII8 Q9HAX2 Q9HAX3 Q9HAX4 |
| sequenceLength | 500 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:62410] PTGIS [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:8957413] PTGIS [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q16647 PTGIS (62411)
