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Details on Person UniProt:Q9NTK5 OLA1
| Class:Id | ReferenceGeneProduct:62399 |
|---|---|
| _chainChangeLog | chain:1-396 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NTK5 OLA1 |
| _timestamp | 2024-11-03 19:42:24 |
| chain | chain:1-396 |
| checksum | 4C7629BFC27CBEB2 |
| comment | FUNCTION Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.COFACTOR Monomer.INTERACTION Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm.ALTERNATIVE PRODUCTS Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.INDUCTION Strongly down-regulated by DNA damage-inducing agents.SIMILARITY Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. |
| description | recommendedName: fullName evidence="1"Obg-like ATPase 1 alternativeName: DNA damage-regulated overexpressed in cancer 45 shortName: DOC45 alternativeName: GTP-binding protein 9 |
| geneName | OLA1 GTPBP9 PRO2455 PTD004 |
| identifier | Q9NTK5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Hydrolase Magnesium Metal-binding Nucleotide-binding Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | OLA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996763] ENSEMBL:ENSG00000138430 OLA1 [Homo sapiens] |
| secondaryIdentifier | OLA1_HUMAN D7EHM2 Q5BJD7 Q8NCI8 Q96CU1 Q96SV2 Q9P1D3 Q9UNY9 Q9Y6G4 |
| sequenceLength | 396 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152555] UniProt:Q9NTK5-2 OLA1 [Homo sapiens] [ReferenceIsoform:152556] UniProt:Q9NTK5-3 OLA1 [Homo sapiens] [ReferenceIsoform:414786] UniProt:Q9NTK5-1 OLA1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8862978] OLA1 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:8863004] OLA1 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NTK5 OLA1 (62399)
