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Details on Person UniProt:P22891 PROZ

Class:Id	ReferenceGeneProduct:62253
_chainChangeLog	signal peptide:1-23 added on Sat February 7 2015;propeptide:24-40 added on Sat February 7 2015;chain:41-400 added on Sat February 7 2015
_displayName	UniProt:P22891 PROZ
_timestamp	2024-11-03 19:38:18
chain	signal peptide:1-23 propeptide:24-40 chain:41-400
checksum	7EBD2DCC48860268
comment	FUNCTION Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.SUBUNIT Interacts with SERPINA10.INTERACTION Plasma.PTM The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.SIMILARITY Belongs to the peptidase S1 family.CAUTION Although related to peptidase S1 family vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues and therefore lacks protease activity.
description	recommendedName: Vitamin K-dependent protein Z
geneName	PROZ
identifier	P22891
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disulfide bond EGF-like domain Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydroxylation Proteomics identification Reference proteome Repeat Secreted Serine protease homolog Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	PROZ
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9002566] ENSEMBL:ENSG00000126231 PROZ [Homo sapiens]
secondaryIdentifier	PROZ_HUMAN A6NMB4 Q15213 Q5JVF5 Q5JVF6
sequenceLength	400
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:152489] UniProt:P22891-2 PROZ [Homo sapiens] [ReferenceIsoform:403354] UniProt:P22891-1 PROZ [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:163813] 13xCbxE-PROZ [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:163816] PROZ(24-400) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:163827] 13xCbxE-PROZ(24-400) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:163834] PROZ(24-40) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:163838] 13xCbxE-PROZ(24-400) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9932942] 13xCbxE-PROZ [extracellular region] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:163792] L-gamma-carboxyglutamic acid at 70 [ModifiedResidue:163793] L-gamma-carboxyglutamic acid at 47 [ModifiedResidue:163799] L-gamma-carboxyglutamic acid at 73 [ModifiedResidue:163801] L-gamma-carboxyglutamic acid at 57 [ModifiedResidue:163808] L-gamma-carboxyglutamic acid at 48 [ModifiedResidue:163817] L-gamma-carboxyglutamic acid at 75 [ModifiedResidue:163821] L-gamma-carboxyglutamic acid at 67 [ModifiedResidue:163822] L-gamma-carboxyglutamic acid at 51 [ModifiedResidue:163823] L-gamma-carboxyglutamic acid at 55 [ModifiedResidue:163829] L-gamma-carboxyglutamic acid at 60 List all 13 refering instances
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No pathways have been reviewed or authored by UniProt:P22891 PROZ (62253)