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Details on Person UniProt:P07225 PROS1

Class:Id	ReferenceGeneProduct:62251
_chainChangeLog	signal peptide:1-24 added on Fri February 6 2015;propeptide:25-41 added on Fri February 6 2015;chain:42-676 added on Fri February 6 2015
_displayName	UniProt:P07225 PROS1
_timestamp	2024-11-03 20:02:39
chain	signal peptide:1-24 propeptide:25-41 chain:42-676
checksum	2B88A04F85403F25
comment	FUNCTION Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.INTERACTION Plasma.PTM The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.
description	recommendedName: Vitamin K-dependent protein S
geneName	PROS1 PROS
identifier	P07225
isSequenceChanged	FALSE
keyword	3D-structure Blood coagulation Calcium Cleavage on pair of basic residues Disease variant Disulfide bond EGF-like domain Fibrinolysis Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydroxylation Proteomics identification Reference proteome Repeat Secreted Signal Thrombophilia Zymogen
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	PROS1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8957675] ENSEMBL:ENSG00000184500 PROS1 [Homo sapiens]
secondaryIdentifier	PROS_HUMAN A8KAC9 D3DN28 Q15518 Q7Z715 Q9UCZ8
sequenceLength	676
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:141004] 11xCbxE-PROS1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:159758] PROS1(25-676) [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:159770] 11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:159792] PROS1(25-41) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:159850] 11xCbxE-PROS1(25-676) [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:159865] 11xCbxE-PROS1 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:202772] 11xCbxE-PROS1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:349762] 11xCbxE-PROS1 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:8958171] PROS1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9949489] 11xCbxE-PROS1 [endosome lumen] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:140994] L-gamma-carboxyglutamic acid at 77 [ModifiedResidue:140995] L-gamma-carboxyglutamic acid at 73 [ModifiedResidue:140996] L-gamma-carboxyglutamic acid at 70 [ModifiedResidue:140997] L-gamma-carboxyglutamic acid at 67 [ModifiedResidue:140998] L-gamma-carboxyglutamic acid at 66 [ModifiedResidue:140999] L-gamma-carboxyglutamic acid at 61 [ModifiedResidue:141000] L-gamma-carboxyglutamic acid at 60 [ModifiedResidue:141001] L-gamma-carboxyglutamic acid at 57 [ModifiedResidue:141002] L-gamma-carboxyglutamic acid at 55 [ModifiedResidue:141003] L-gamma-carboxyglutamic acid at 48 List all 11 refering instances
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No pathways have been reviewed or authored by UniProt:P07225 PROS1 (62251)