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Details on Person UniProt:P10619 CTSA
| Class:Id | ReferenceGeneProduct:62249 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Sat February 7 2015;chain:29-480 added on Sat February 7 2015;chain:29-326 added on Sat February 7 2015;chain:327-480 added on Sat February 7 2015 |
| _displayName | UniProt:P10619 CTSA |
| _timestamp | 2024-11-03 20:11:35 |
| chain | signal peptide:1-28 chain:29-480 chain:29-326 chain:327-480 |
| checksum | 46B737DEE775C508 |
| comment | FUNCTION Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.CATALYTIC ACTIVITY Release of a C-terminal amino acid with broad specificity.SUBUNIT Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S10 family. |
| description | recommendedName: Lysosomal protective protein ecNumber: 3.4.16.5 alternativeName: Carboxypeptidase C alternativeName: Carboxypeptidase L alternativeName: Cathepsin A alternativeName: Protective protein cathepsin A shortName: PPCA alternativeName: Protective protein for beta-galactosidase component recommendedName: Lysosomal protective protein 32 kDa chain /component component recommendedName: Lysosomal protective protein 20 kDa chain /component |
| geneName | CTSA PPGB |
| identifier | P10619 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Carboxypeptidase Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hydrolase Lysosome Protease Proteomics identification Reference proteome Signal Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CTSA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957457] ENSEMBL:ENSG00000064601 CTSA [Homo sapiens] |
| secondaryIdentifier | PPGB_HUMAN B2R798 Q561W6 Q5JZH1 Q96KJ2 Q9BR08 Q9BW68 |
| sequenceLength | 480 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969808] UniProt:P10619-1 CTSA [Homo sapiens] [ReferenceIsoform:8969809] UniProt:P10619-2 CTSA [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1181230] CTSA(29-480) [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:1605642] CTSA(327-480) [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:1605735] CTSA(29-326) [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:6799120] CTSA(327-480) [azurophil granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6799135] CTSA(29-326) [azurophil granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806187] CTSA(29-326) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6806233] CTSA(327-480) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8957458] CTSA [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P10619 CTSA (62249)
