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Details on Person UniProt:P62195 PSMC5
| Class:Id | ReferenceGeneProduct:62228 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-406 added on Sat February 7 2015;initiator methionine:1 for 62228 removed on Fri Nov 03 2023;initiator methionine: for 62228 added on Fri Nov 03 2023;initiator methionine: for 62228 removed on Fri Aug 15 2025;initiator methionine:1 for 62228 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62195 PSMC5 |
| _timestamp | 2025-08-15 21:33:05 |
| chain | initiator methionine:1 chain:2-406 |
| checksum | 29C6410C4A85A7F7 |
| comment | FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components (PubMed:27342858, PubMed:27428775). Component of a complex with USP49 and RUVBL1 (PubMed:23824326). Interacts with PRPF19. Interacts with TRIM5 (PubMed:22078707). Interacts with NDC80 (PubMed:10409732, PubMed:9295362). Interacts with PAAF1 (PubMed:15831487). Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (By similarity). Interacts with ERCC6 (PubMed:26030138).INTERACTION Belongs to the AAA ATPase family. |
| description | recommendedName: 26S proteasome regulatory subunit 8 alternativeName: 26S proteasome AAA-ATPase subunit RPT6 alternativeName: Proteasome 26S subunit ATPase 5 alternativeName: Proteasome subunit p45 alternativeName: Thyroid hormone receptor-interacting protein 1 shortName: TRIP1 alternativeName: p45/SUG |
| geneName | PSMC5 SUG1 |
| identifier | P62195 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Nucleotide-binding Nucleus Phosphoprotein Proteasome Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PSMC5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996809] ENSEMBL:ENSG00000087191 PSMC5 [Homo sapiens] |
| secondaryIdentifier | PRS8_HUMAN A8K3Z3 A8K763 O35051 O43208 P47210 P52915 P52916 |
| sequenceLength | 406 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8964929] UniProt:P62195-1 PSMC5 [Homo sapiens] [ReferenceIsoform:8964930] UniProt:P62195-2 PSMC5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68780] PSMC5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174312] PSMC5 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P62195 PSMC5 (62228)
