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Details on Person UniProt:O43272 PRODH
| Class:Id | ReferenceGeneProduct:62190 |
|---|---|
| _chainChangeLog | transit peptide:1- added on Fri February 6 2015;chain:-600 added on Fri February 6 2015 |
| _displayName | UniProt:O43272 PRODH |
| _timestamp | 2025-02-21 19:00:35 |
| chain | transit peptide:1- chain:-600 |
| checksum | 6283BBD016EFAA36 |
| comment | FUNCTION Converts proline to delta-1-pyrroline-5-carboxylate.CATALYTIC ACTIVITY L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)COFACTOR Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.SUBCELLULAR LOCATION Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.INDUCTION During p53/TP53-induced apoptosis.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the proline oxidase family.SEQUENCE CAUTION Artifact. Missing internal sequence that doesn't correspond to an exon-intron boundary.SEQUENCE CAUTION Intron retention. Includes intronic sequence at the 5' end. |
| description | recommendedName: fullName evidence="15"Proline dehydrogenase 1, mitochondrial ecNumber evidence="7"1.5.5.2 alternativeName: Proline oxidase alternativeName: Proline oxidase 2 alternativeName: p53-induced gene 6 protein |
| geneName | PRODH PIG6 POX2 PRODH2 |
| identifier | O43272 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Disease variant FAD Flavoprotein Mitochondrion Oxidoreductase Proline metabolism Proteomics identification Reference proteome Schizophrenia Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PRODH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002565] ENSEMBL:ENSG00000100033 PRODH [Homo sapiens] |
| secondaryIdentifier | PROD_HUMAN A0A087WWM6 A6NF53 O14680 Q0P507 Q147W8 Q504W1 Q59FI8 Q6NV86 Q9UF13 |
| sequenceLength | 600 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:243948] UniProt:O43272-2 PRODH [Homo sapiens] [ReferenceIsoform:243950] UniProt:O43272-4 PRODH [Homo sapiens] [ReferenceIsoform:401500] UniProt:O43272-1 PRODH [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:70668] PRODH [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O43272 PRODH (62190)
