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Details on Person UniProt:P09923 ALPI
| Class:Id | ReferenceGeneProduct:62036 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Sat February 7 2015;chain:20-503 added on Sat February 7 2015;propeptide:504-528 added on Sat February 7 2015 |
| _displayName | UniProt:P09923 ALPI |
| _timestamp | 2024-11-03 19:58:04 |
| chain | signal peptide:1-19 chain:20-503 propeptide:504-528 |
| checksum | 465306BEDF9F0B79 |
| comment | FUNCTION Alkaline phosphatase that can hydrolyze various phosphate compounds.CATALYTIC ACTIVITY a phosphate monoester + H2O = an alcohol + phosphateCOFACTOR Binds 1 Mg(2+) ion.COFACTOR Binds 2 Zn(2+) ions.COFACTOR Homodimer.INTERACTION In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP).SIMILARITY Belongs to the alkaline phosphatase family.ONLINE INFORMATION Alkaline phosphatase entry |
| description | recommendedName: Intestinal-type alkaline phosphatase shortName: IAP shortName: Intestinal alkaline phosphatase ecNumber: 3.1.3.1 |
| geneName | ALPI |
| identifier | P09923 |
| isSequenceChanged | FALSE |
| keyword | Calcium Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Hydrolase Lipoprotein Magnesium Membrane Metal-binding Proteomics identification Reference proteome Signal Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ALPI |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993241] ENSEMBL:ENSG00000163295 ALPI [Homo sapiens] |
| secondaryIdentifier | PPBI_HUMAN B2R7Y4 Q53S80 Q9UBV5 Q9UCL2 |
| sequenceLength | 528 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8878783] ALPI [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8940717] GPI-ALPI [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8943401] cleaved GPI-ALPI [extracellular region] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:8940769] L-aspartic acid 1-amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 503 [GroupModifiedResidue:8941136] L-aspartic acid 1-amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 503 |
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No pathways have been reviewed or authored by UniProt:P09923 ALPI (62036)
