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Details on Person UniProt:Q9Y277 VDAC3
| Class:Id | ReferenceGeneProduct:61990 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-283 added on Fri February 6 2015;initiator methionine:1 for 61990 removed on Fri Nov 03 2023;initiator methionine: for 61990 added on Fri Nov 03 2023;initiator methionine: for 61990 removed on Fri Aug 15 2025;initiator methionine:1 for 61990 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9Y277 VDAC3 |
| _timestamp | 2026-02-20 21:55:42 |
| chain | initiator methionine:1 chain:2-283 |
| checksum | E03CBCEDA72A9783 |
| comment | FUNCTION Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:31935282). Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (PubMed:31935282). Involved in male fertility and sperm mitochondrial sheath formation (By similarity).CATALYTIC ACTIVITY chloride(in) = chloride(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)SUBUNIT Interacts with ARMC12 in a TBC1D21-dependent manner (By similarity). Interacts with MISFA (By similarity).SUBCELLULAR LOCATION May localize to non-mitochondrial membranes.ALTERNATIVE PRODUCTS Expressed in erythrocytes (at protein level) (PubMed:27641616). Widely expressed. Highest in testis (PubMed:9781040).DOMAIN Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.PTM Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.SIMILARITY Belongs to the eukaryotic mitochondrial porin family. |
| description | recommendedName: fullName evidence="11"Non-selective voltage-gated ion channel VDAC3 shortName: VDAC-3 shortName evidence="10"hVDAC3 alternativeName: Outer mitochondrial membrane protein porin 3 |
| geneName | VDAC3 |
| identifier | Q9Y277 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing ATP-binding Ion transport Isopeptide bond Membrane Mitochondrion Mitochondrion outer membrane NAD Nucleotide-binding Phosphoprotein Porin Proteomics identification Reference proteome Transmembrane Transmembrane beta strand Transport Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | VDAC3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996965] ENSEMBL:ENSG00000078668 VDAC3 [Homo sapiens] |
| secondaryIdentifier | VDAC3_HUMAN Q9UIS0 |
| sequenceLength | 283 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152331] UniProt:Q9Y277-2 VDAC3 [Homo sapiens] [ReferenceIsoform:415923] UniProt:Q9Y277-1 VDAC3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5696901] VDAC3 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:6783045] PolyUb-VDAC3 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:9835015] Ub-VDAC3 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:9835016] p-S65-Ub:VDAC3 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:9843310] K63polyUb-VDAC3 [mitochondrial outer membrane] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:6783198] ubiquitinylated lysine (PolyUb [mitochondrial outer membrane]) at unknown position [GroupModifiedResidue:9834941] ubiquitinylated lysine (p-S65-Ub [mitochondrial outer membrane]) at unknown position [GroupModifiedResidue:9834965] ubiquitinylated lysine (Ub [mitochondrial outer membrane]) at unknown position [GroupModifiedResidue:9843315] ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q9Y277 VDAC3 (61990)
