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Details on Person UniProt:P14859 POU2F1
| Class:Id | ReferenceGeneProduct:61940 |
|---|---|
| _chainChangeLog | chain:1-743 added on Sat February 7 2015 |
| _displayName | UniProt:P14859 POU2F1 |
| _timestamp | 2024-11-03 20:16:01 |
| chain | chain:1-743 |
| checksum | FAB27FFC79CF2276 |
| comment | FUNCTION Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.FUNCTION (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.SUBUNIT Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity (PubMed:7859290). Interacts with NR3C1, AR, PGR and HCFC1.SUBUNIT (Microbial infection) Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.SUBUNIT (Microbial infection) Interacts with human herpesvirus 8 (KSHV) protein RTA/ORF50; this interaction enhances RTA/ORF50-mediated transactivation of several viral promoters including K-bZIP promoter.INTERACTION Ubiquitous. Isoform 2 is lymphocyte-specific.PTM Phosphorylated by PRKDC.SIMILARITY Belongs to the POU transcription factor family. Class-2 subfamily. |
| description | recommendedName: POU domain, class 2, transcription factor 1 alternativeName: NF-A1 alternativeName: Octamer-binding protein 1 shortName: Oct-1 alternativeName: Octamer-binding transcription factor 1 shortName: OTF-1 |
| geneName | POU2F1 OCT1 OTF1 |
| identifier | P14859 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing DNA-binding Homeobox Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | POU2F1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8948466] ENSEMBL:ENSG00000143190 POU2F1 [Homo sapiens] |
| secondaryIdentifier | PO2F1_HUMAN B1AL91 B1AL93 B4E029 J3KP77 Q5TBT7 Q6PK46 Q8NEU9 Q9BPV1 |
| sequenceLength | 743 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152283] UniProt:P14859-2 POU2F1 [Homo sapiens] [ReferenceIsoform:243405] UniProt:P14859-3 POU2F1 [Homo sapiens] [ReferenceIsoform:243406] UniProt:P14859-4 POU2F1 [Homo sapiens] [ReferenceIsoform:402969] UniProt:P14859-1 POU2F1 [Homo sapiens] [ReferenceIsoform:8969806] UniProt:P14859-5 POU2F1 [Homo sapiens] [ReferenceIsoform:8969807] UniProt:P14859-6 POU2F1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:83836] POU2F1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P14859 POU2F1 (61940)
