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Details on Person UniProt:P18669 PGAM1
| Class:Id | ReferenceGeneProduct:61882 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-254 added on Fri February 6 2015;initiator methionine:1 for 61882 removed on Fri Nov 03 2023;initiator methionine: for 61882 added on Fri Nov 03 2023;initiator methionine: for 61882 removed on Fri Aug 15 2025;initiator methionine:1 for 61882 added on Fri Aug 15 2025 |
| _displayName | UniProt:P18669 PGAM1 |
| _timestamp | 2026-02-20 22:36:37 |
| chain | initiator methionine:1 chain:2-254 |
| checksum | 6DC0852BEBB22409 |
| comment | FUNCTION Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate, a crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202).CATALYTIC ACTIVITY (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerateCATALYTIC ACTIVITY (2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)SUBUNIT Homodimer.INTERACTION Expressed in the liver and brain. Not found in the muscle.PTM Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.SIMILARITY Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. |
| description | recommendedName: fullName evidence="9"Phosphoglycerate mutase 1 ecNumber evidence="6"5.4.2.11 ecNumber evidence="6"5.4.2.4 alternativeName: BPG-dependent PGAM 1 alternativeName: Phosphoglycerate mutase isozyme B shortName: PGAM-B |
| geneName | PGAM1 PGAMA CDABP0006 |
| identifier | P18669 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Glycolysis Hydrolase Isomerase Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | PGAM1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957588] ENSEMBL:ENSG00000171314 PGAM1 [Homo sapiens] |
| secondaryIdentifier | PGAM1_HUMAN Q9BWC0 |
| sequenceLength | 254 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:71442] PGAM1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6803293] PGAM1 [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6803309] PGAM1 [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6803351] PGAM1 [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:6806482] PGAM1 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P18669 PGAM1 (61882)
