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Details on Person UniProt:P00747 PLG

Class:Id	ReferenceGeneProduct:61838
_chainChangeLog	signal peptide:1-19 added on Sat February 7 2015;chain:20-810 added on Sat February 7 2015;chain:20-580 added on Sat February 7 2015;peptide:20-97 added on Sat February 7 2015;chain:79-466 added on Sat February 7 2015;chain:98-580 added on Sat February 7 2015;chain:581-810 added on Sat February 7 2015
_displayName	UniProt:P00747 PLG
_timestamp	2025-08-15 21:25:27
chain	signal peptide:1-19 chain:20-810 chain:20-580 peptide:20-97 chain:79-466 chain:98-580 chain:581-810
checksum	8B31CB877CCB3AB6
comment	FUNCTION Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5 (PubMed:6447255). Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.FUNCTION Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.FUNCTION (Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete (PubMed:21949403). The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut (PubMed:21949403).FUNCTION (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue.FUNCTION (Microbial infection) Interacts with dengue virus type 2 particles (PubMed:31726374). Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed:31726374).CATALYTIC ACTIVITY Preferential cleavage: Lys-\|-Xaa > Arg-\|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.ACTIVITY REGULATION Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2.SUBUNIT Interacts (both mature PLG and the angiostatin peptide) with CSPG4 and AMOT (PubMed:10889192, PubMed:16043488). Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation (PubMed:19712047, PubMed:9102401). Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824). Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin (PubMed:10077593). Interacts (plasmin) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392). Interacts (plasmin) with iripin-1, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:36756125). Interacts (plasmin) with Kazal-type trypsin inhibitor, a serine protease inhibitor from Aedes aegypti (PubMed:31726374, PubMed:34800067).SUBUNIT (Microbial infection) Interacts with C.albicans GPD2; the interaction is direct and provides active plasmin on the surface of fungal cells.SUBUNIT (Microbial infection) Interacts with Staphylococcus aureus protein FnbB; this interaction provides active plasmin on the surface of bacterial cells.SUBUNIT (Microbial infection) Interacts with P.falciparum (strain NF54) enolase ENO (via DKSLVK motif); the interaction occurs at the ookinete cell surface and is required for ookinete invasion of the mosquito midgut.SUBUNIT (Microbial infection) Interacts with B.burgdorferi OspC.INTERACTION Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.TISSUE SPECIFICITY Present in plasma and many other extracellular fluids. It is synthesized in the liver.DOMAIN Kringle domains mediate interaction with CSPG4.PTM N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).PTM In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.PTM (Microbial infection) The Y.pestis Pla protein cleaves between Arg-580 and Val-581, generating plasmin which facilitates bacterial migration and infection (PubMed:22645135).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.SIMILARITY Belongs to the peptidase S1 family. Plasminogen subfamily.ONLINE INFORMATION Plasmin entry
description	recommendedName: fullName evidence="48"Plasminogen ecNumber evidence="17 37"3.4.21.7 component recommendedName: Plasmin heavy chain A /component component recommendedName: Activation peptide /component component recommendedName: fullName evidence="49"Angiostatin /component component recommendedName: Plasmin heavy chain A, short form /component component recommendedName: Plasmin light chain B /component
geneName	PLG
identifier	P00747
isSequenceChanged	FALSE
keyword	3D-structure Blood coagulation Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond Fibrinolysis Glycoprotein Hemostasis Hydrolase Kringle Phosphoprotein Protease Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Thrombophilia Tissue remodeling Zymogen
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	PLG
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8995619] ENSEMBL:ENSG00000122194 PLG [Homo sapiens]
secondaryIdentifier	PLMN_HUMAN Q15146 Q5TEH4 Q6PA00
sequenceLength	810
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:61837] PLG(1-810) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:114647] PLG(20-810) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:158701] PLG(20-810) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158775] PLG(581-810) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158783] PLG(20-580) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158923] PLG(20-810) [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P00747 PLG (61838)