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Details on Person UniProt:O60240 PLIN1
| Class:Id | ReferenceGeneProduct:61828 |
|---|---|
| _chainChangeLog | chain:1-522 added on Fri February 6 2015 |
| _displayName | UniProt:O60240 PLIN1 |
| _timestamp | 2024-11-03 19:38:11 |
| chain | chain:1-522 |
| checksum | 394FC14388EB5DCC |
| comment | FUNCTION Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.SUBUNIT Interacts with ABHD5 (By similarity). Interacts with CIDEC (PubMed:23399566). Interacts with AQP7 (PubMed:27832861).INTERACTION Lipid droplet surface-associated.TISSUE SPECIFICITY Detected in adipocytes from white adipose tissue (at protein level) (PubMed:27832861). Detected in visceral adipose tissue and mammary gland (PubMed:9521880).PTM Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the perilipin family.ONLINE INFORMATION Fat, wonderful fat - Issue 10 of May 2001 |
| description | recommendedName: Perilipin-1 alternativeName: Lipid droplet-associated protein |
| geneName | PLIN1 PERI PLIN |
| identifier | O60240 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Lipid droplet Lipid metabolism Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PLIN1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5640208] ENSEMBL:ENSG00000166819 PLIN1 [Homo sapiens] |
| secondaryIdentifier | PLIN1_HUMAN Q8N5Y6 |
| sequenceLength | 522 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:163460] PLIN1 [lipid droplet] [Homo sapiens] [EntityWithAccessionedSequence:163561] p-S81,S277-PLIN1 [lipid droplet] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:163487] O-phospho-L-serine at 277 [ModifiedResidue:163534] O-phospho-L-serine at 81 |
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No pathways have been reviewed or authored by UniProt:O60240 PLIN1 (61828)
