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Details on Person UniProt:P02776 PF4
| Class:Id | ReferenceGeneProduct:61824 |
|---|---|
| _chainChangeLog | signal peptide:1-31 added on Fri February 6 2015;chain:32-101 added on Fri February 6 2015;chain:48-101 added on Fri February 6 2015 |
| _displayName | UniProt:P02776 PF4 |
| _timestamp | 2025-02-21 19:52:21 |
| chain | signal peptide:1-31 chain:32-101 chain:48-101 |
| checksum | E96C2EFE9B944D85 |
| comment | FUNCTION Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation (PubMed:29930254, PubMed:9531587). Acts via different functional receptors including CCR1, CXCR3A or CXCR3B (PubMed:18174362, PubMed:29930254). Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling (PubMed:18174362, PubMed:24469069). Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence (PubMed:9531587). Chemotactic for neutrophils and monocytes via CCR1 (PubMed:29930254). Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis (PubMed:35701499). In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition (PubMed:34986347). Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity (PubMed:9395524).SUBUNIT Homotetramer (PubMed:7547867, PubMed:8031770). Interacts with TNFAIP6 (via Link domain) (PubMed:27044744). Interacts with CCR1 (PubMed:29930254). Interacts with CXCR3 (PubMed:18174362). Interacts with THBD; this interaction enhances generation of activated protein C (PubMed:9395524).INTERACTION By inflammatory conditions.MASS SPECTROMETRY Short form.SIMILARITY Belongs to the intercrine alpha (chemokine CxC) family.ONLINE INFORMATION CXCL4 entry |
| description | recommendedName: Platelet factor 4 shortName: PF-4 alternativeName: C-X-C motif chemokine 4 alternativeName: Iroplact alternativeName: Oncostatin-A component recommendedName: Platelet factor 4, short form alternativeName: fullName evidence="17"Endothelial cell growth inhibitor /component |
| geneName | PF4 CXCL4 SCYB4 |
| identifier | P02776 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Heparin-binding Phosphoprotein Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PF4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8938183] ENSEMBL:ENSG00000163737 PF4 [Homo sapiens] |
| secondaryIdentifier | PLF4_HUMAN Q53X61 Q9UC64 Q9UC65 |
| sequenceLength | 101 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:61823] PF4(32-101) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:114628] PF4(48-101) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:114629] PF4(48-101) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:114652] PF4(32-101) [platelet alpha granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P02776 PF4 (61824)
