Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q9NRZ7 AGPAT3

Class:Id	ReferenceGeneProduct:61808
_chainChangeLog	chain:1-376 added on Fri February 6 2015
_displayName	UniProt:Q9NRZ7 AGPAT3
_timestamp	2025-05-21 21:38:40
chain	chain:1-376
checksum	C12CDBB7CC363852
comment	FUNCTION Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Also has a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).CATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY pentadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY nonadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-heptadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-octadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoABIOPHYSICOCHEMICAL PROPERTIES Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.INTERACTION Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.DOMAIN The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.SIMILARITY Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
description	recommendedName: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma ecNumber evidence="4"2.3.1.51 alternativeName: 1-acylglycerol-3-phosphate O-acyltransferase 3 shortName: 1-AGP acyltransferase 3 shortName: 1-AGPAT 3 alternativeName: Lysophosphatidic acid acyltransferase gamma shortName: LPAAT-gamma
geneName	AGPAT3 LPAAT3 UNQ759/PRO1490
identifier	Q9NRZ7
isSequenceChanged	FALSE
keyword	Acyltransferase Alternative splicing Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Nucleus Phospholipid biosynthesis Phospholipid metabolism Proteomics identification Reference proteome Transferase Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
name	AGPAT3
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8988580] ENSEMBL:ENSG00000160216 AGPAT3 [Homo sapiens]
secondaryIdentifier	PLCC_HUMAN D3DSL2 Q3ZCU2 Q6UWP6 Q6ZUC6 Q8N3Q7 Q9NRZ6
sequenceLength	376
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:152203] UniProt:Q9NRZ7-2 AGPAT3 [Homo sapiens] [ReferenceIsoform:243133] UniProt:Q9NRZ7-3 AGPAT3 [Homo sapiens] [ReferenceIsoform:414750] UniProt:Q9NRZ7-1 AGPAT3 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:61807] AGPAT3 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:8849239] AGPAT3 [Golgi membrane] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q9NRZ7 AGPAT3 (61808)