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Details on Person UniProt:O15120 AGPAT2

Class:Id	ReferenceGeneProduct:61806
_chainChangeLog	signal peptide:1-23 added on Fri February 6 2015;chain:24-278 added on Fri February 6 2015
_displayName	UniProt:O15120 AGPAT2
_timestamp	2025-02-21 19:21:15
chain	signal peptide:1-23 chain:24-278
checksum	1E58F537F703BE9F
comment	FUNCTION Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.CATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY pentadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-tetradecanoyl-sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-eicosanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoACATALYTIC ACTIVITY (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoABIOPHYSICOCHEMICAL PROPERTIES Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.SUBCELLULAR LOCATION Expressed predominantly in adipose tissue, pancreas and liver.DOMAIN The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
description	recommendedName: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta ecNumber evidence="4 5 6 7"2.3.1.51 alternativeName: 1-acylglycerol-3-phosphate O-acyltransferase 2 shortName: 1-AGP acyltransferase 2 shortName: 1-AGPAT 2 alternativeName: fullName evidence="9"Lysophosphatidic acid acyltransferase beta shortName: LPAAT-beta
geneName	AGPAT2
identifier	O15120
isSequenceChanged	FALSE
keyword	Acyltransferase Alternative splicing Congenital generalized lipodystrophy Diabetes mellitus Disease variant Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Phospholipid biosynthesis Phospholipid metabolism Proteomics identification Reference proteome Signal Transferase Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	AGPAT2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000252] ENSEMBL:ENSG00000169692 AGPAT2 [Homo sapiens]
secondaryIdentifier	PLCB_HUMAN O00516 O15106 Q5VUD3 Q5VUD4 Q9BSV7 Q9BWR7
sequenceLength	278
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:152202] UniProt:O15120-2 AGPAT2 [Homo sapiens] [ReferenceIsoform:401305] UniProt:O15120-1 AGPAT2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:61805] AGPAT2 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799353] AGPAT2 [specific granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6806317] AGPAT2 [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O15120 AGPAT2 (61806)