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Details on Person UniProt:P14923 JUP
| Class:Id | ReferenceGeneProduct:61798 |
|---|---|
| _chainChangeLog | chain:1-745 added on Sat February 7 2015 |
| _displayName | UniProt:P14923 JUP |
| _timestamp | 2026-02-20 22:02:43 |
| chain | chain:1-745 |
| checksum | 3519A0973748BCF4 |
| comment | FUNCTION Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity).SUBUNIT Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Identified in a complex containing at least DSP, JUP, VIM and CDH2; the complex is more abundant following crush injury in regenerating motor neurons and may promote axon outgrowth and motor fiber repair (By similarity). Interacts with MUC1. Interacts with CAV1 (By similarity). Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 (PubMed:11790773, PubMed:22781308). Interacts with PKP3 (via N-terminus); the interaction is required for PKP3 localization to desmosome cell-cell junctions (PubMed:20859650). Interacts with DSG4 (PubMed:21495994).INTERACTION Cytoplasmic in a soluble and membrane-associated form. Colocalizes with DSG4 at desmosomes (PubMed:21495994).TISSUE SPECIFICITY Expressed in cardiomyocytes in the heart (at protein level).DOMAIN The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region.PTM Cleaved by CASP3 in response to apoptosis.PTM May be phosphorylated by FER.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the beta-catenin family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Junction plakoglobin alternativeName: Catenin gamma alternativeName: Desmoplakin III alternativeName: Desmoplakin-3 |
| geneName | JUP CTNNG DP3 |
| identifier | P14923 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cardiomyopathy Cell adhesion Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Glycoprotein Membrane Nucleus Palmoplantar keratoderma Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | JUP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962447] ENSEMBL:ENSG00000173801 JUP [Homo sapiens] |
| secondaryIdentifier | PLAK_HUMAN Q15093 Q15151 Q7L3S5 Q86W21 Q9BWC4 Q9HCX9 |
| sequenceLength | 745 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:201598] JUP [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:201986] JUP [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:437260] JUP [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799534] JUP [specific granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801028] JUP [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806309] JUP [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8847739] JUP [cornified envelope] [Homo sapiens] [EntityWithAccessionedSequence:9934829] p-Y-JUP [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9934826] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:P14923 JUP (61798)
