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Details on Person UniProt:Q00722 PLCB2
| Class:Id | ReferenceGeneProduct:61696 |
|---|---|
| _chainChangeLog | chain:1-1185 added on Fri February 6 2015 |
| _displayName | UniProt:Q00722 PLCB2 |
| _timestamp | 2024-11-03 20:07:01 |
| chain | chain:1-1185 |
| checksum | A0397309D943672A |
| comment | FUNCTION The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:1644792, PubMed:9188725). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity).CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)COFACTOR Binds 1 Ca(2+) ion per subunit.SUBUNIT Interacts with RAC1 (PubMed:1644792). Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2 (PubMed:23625927).INTERACTION The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16. |
| description | recommendedName: fullName evidence="14"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 ecNumber evidence="11"3.1.4.11 alternativeName: Phosphoinositide phospholipase C-beta-2 alternativeName: Phospholipase C-beta-2 shortName: PLC-beta-2 |
| geneName | PLCB2 |
| identifier | Q00722 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Coiled coil Hydrolase Lipid degradation Lipid metabolism Metal-binding Phosphoprotein Proteomics identification Reference proteome Transducer |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PLCB2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998522] ENSEMBL:ENSG00000137841 PLCB2 [Homo sapiens] |
| secondaryIdentifier | PLCB2_HUMAN A8K6J2 B9EGH5 |
| sequenceLength | 1185 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:385833] UniProt:Q00722-2 PLCB2 [Homo sapiens] [ReferenceIsoform:405004] UniProt:Q00722-1 PLCB2 [Homo sapiens] [ReferenceIsoform:8970199] UniProt:Q00722-3 PLCB2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:61695] PLCB2 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q00722 PLCB2 (61696)
