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Details on Person UniProt:P11216 PYGB
| Class:Id | ReferenceGeneProduct:61668 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-843 added on Fri February 6 2015;initiator methionine:1 for 61668 removed on Fri Nov 03 2023;initiator methionine: for 61668 added on Fri Nov 03 2023;initiator methionine: for 61668 removed on Fri Aug 15 2025;initiator methionine:1 for 61668 added on Fri Aug 15 2025 |
| _displayName | UniProt:P11216 PYGB |
| _timestamp | 2025-08-15 22:03:33 |
| chain | initiator methionine:1 chain:2-843 |
| checksum | 810BFAD3002CACB0 |
| comment | FUNCTION Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228).CATALYTIC ACTIVITY [(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphateCOFACTOR Activity of phosphorylase is controlled both by allosteric means (through the non-covalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B. Activated upon phosphorylation.SUBUNIT Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.INTERACTION Phosphorylated (PubMed:27402852). Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A (By similarity).SIMILARITY Belongs to the glycogen phosphorylase family. |
| description | recommendedName: fullName evidence="8"Glycogen phosphorylase, brain form ecNumber evidence="6"2.4.1.1 |
| geneName | PYGB |
| identifier | P11216 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Allosteric enzyme Carbohydrate metabolism Direct protein sequencing Glycogen metabolism Glycosyltransferase Phosphoprotein Proteomics identification Pyridoxal phosphate Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PYGB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999104] ENSEMBL:ENSG00000100994 PYGB [Homo sapiens] |
| secondaryIdentifier | PYGB_HUMAN Q96AK1 Q9NPX8 |
| sequenceLength | 843 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:71862] PXLP-PYGB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:71868] PXLP-p-S15-PYGB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6799164] PXLP-PYGB [azurophil granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801536] PXLP-PYGB [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:71867] O-phospho-L-serine at 15 [ModifiedResidue:453353] N6-pyridoxal phosphate-L-lysine at 681 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P11216 PYGB (61668)
