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Details on Person UniProt:P10124 SRGN
| Class:Id | ReferenceGeneProduct:61630 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Fri February 6 2015;chain:28-158 added on Fri February 6 2015 |
| _displayName | UniProt:P10124 SRGN |
| _timestamp | 2026-02-20 22:16:26 |
| chain | signal peptide:1-27 chain:28-158 |
| checksum | BD7767F39FFBC477 |
| comment | FUNCTION Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization.SUBUNIT Binds to activated CD44 and to GZMB.INTERACTION Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585).INDUCTION By Epstein-Barr virus (EBV).PTM O-glycosylated; contains chondroitin sulfate and heparan sulfate.SIMILARITY Belongs to the serglycin family. |
| description | recommendedName: Serglycin alternativeName: Hematopoietic proteoglycan core protein alternativeName: Platelet proteoglycan core protein shortName: P.PG alternativeName: Secretory granule proteoglycan core protein |
| geneName | SRGN PRG PRG1 |
| identifier | P10124 |
| isSequenceChanged | FALSE |
| keyword | Apoptosis Biomineralization Direct protein sequencing Disulfide bond Glycoprotein Golgi apparatus Lysosome Proteoglycan Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SRGN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999171] ENSEMBL:ENSG00000122862 SRGN [Homo sapiens] |
| secondaryIdentifier | SRGN_HUMAN B2R4L7 Q5VW06 |
| sequenceLength | 158 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:349747] SRGN [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:349749] SRGN [platelet alpha granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P10124 SRGN (61630)
