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Details on Person UniProt:P21810 BGN

Class:Id	ReferenceGeneProduct:61626
_chainChangeLog	signal peptide:1-19 added on Fri February 6 2015;propeptide:20-37 added on Fri February 6 2015;chain:38-368 added on Fri February 6 2015;signal peptide:1-19 removed on Fri August 12 2016;propeptide:20-37 removed on Fri August 12 2016;signal peptide:1-16 added on Fri August 12 2016;propeptide:17-37 added on Fri August 12 2016
_displayName	UniProt:P21810 BGN
_timestamp	2024-11-03 20:06:57
chain	signal peptide:1-16 propeptide:17-37 chain:38-368
checksum	BF16F304C5CD3B3E
comment	FUNCTION May be involved in collagen fiber assembly.SUBUNIT Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity).INTERACTION Detected in placenta (at protein level) (PubMed:32337544). Found in several connective tissues, especially in articular cartilages.PTM The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
description	recommendedName: Biglycan alternativeName: Bone/cartilage proteoglycan I alternativeName: PG-S1
geneName	BGN SLRR1A
identifier	P21810
isSequenceChanged	FALSE
keyword	Aortic aneurysm Direct protein sequencing Disease variant Disulfide bond Dwarfism Extracellular matrix Glycoprotein Leucine-rich repeat Proteoglycan Proteomics identification Reference proteome Repeat Secreted Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	BGN
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8957922] ENSEMBL:ENSG00000182492 BGN [Homo sapiens]
secondaryIdentifier	PGS1_HUMAN D3DWU3 P13247
sequenceLength	368
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:2063957] Gal-Gal-Xyl-BGN [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2063968] C4S-BGN [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2064015] XylS-BGN [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064017] C6S-BGN [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2064026] chondroitin(1)-BGN [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064103] Gal-Xyl-BGN [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064135] chondroitin(2)-BGN [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064154] chondroitin(3)-BGN [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064187] CSE-BGN [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2064193] C4S-BGN [Golgi lumen] [Homo sapiens] List all 34 refering instances
(referenceSequence)	[GroupModifiedResidue:2063981] O-xylosyl-L-serine (O3-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2064001] O-xylosyl-L-serine (ChEBI:63512) at unknown position [GroupModifiedResidue:2064008] O-xylosyl-L-serine (O3-(N-acetyl-β-D-galactosaminyl-(1→4)-β-D-glucuronosyl-(1→3)-β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2064024] O-xylosyl-L-serine (ChEBI:63511) at unknown position [GroupModifiedResidue:2064090] O-xylosyl-L-serine (ChEBI:63515) at unknown position [GroupModifiedResidue:2064091] O-xylosyl-L-serine (ChEBI:63513) at unknown position [GroupModifiedResidue:2064116] O-xylosyl-L-serine (3-O-(β-D-glucuronosyl-(1→3)-β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2064119] O-xylosyl-L-serine (ChEBI:63509) at unknown position [GroupModifiedResidue:2064140] O-xylosyl-L-serine (O3-(4-β-D-galactosyl-β-D-xylosyl)-L-serine residue) at unknown position [ModifiedResidue:2064203] O-xylosyl-L-serine at unknown position List all 17 refering instances
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No pathways have been reviewed or authored by UniProt:P21810 BGN (61626)