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Details on Person UniProt:O75381 PEX14

Class:Id	ReferenceGeneProduct:61554
_chainChangeLog	initiator methionine:1 added on Sat February 7 2015;chain:2-377 added on Sat February 7 2015;initiator methionine:1 for 61554 removed on Fri Nov 03 2023;initiator methionine: for 61554 added on Fri Nov 03 2023;initiator methionine: for 61554 removed on Fri Aug 15 2025;initiator methionine:1 for 61554 added on Fri Aug 15 2025
_displayName	UniProt:O75381 PEX14
_timestamp	2025-08-15 21:25:19
chain	initiator methionine:1 chain:2-377
checksum	FED28F62A0B94E7F
comment	FUNCTION Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035).SUBUNIT Interacts with PEX13; forming the PEX13-PEX14 docking complex (PubMed:28765278, PubMed:9653144). Interacts with PEX5 (via WxxxF/Y motifs) (PubMed:11438541, PubMed:12488033, PubMed:19197237, PubMed:21976670, PubMed:24235149, PubMed:28765278, PubMed:9653144). Interacts with PEX19 (PubMed:10704444, PubMed:12488033). Interacts with tubulin (PubMed:21525035).INTERACTION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peroxin-14 family.
description	recommendedName: fullName evidence="18"Peroxisomal membrane protein PEX14 alternativeName: PTS1 receptor-docking protein alternativeName: fullName evidence="18"Peroxin-14 alternativeName: Peroxisomal membrane anchor protein PEX14
geneName	PEX14
identifier	O75381
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Direct protein sequencing Membrane Peroxisome Peroxisome biogenesis disorder Phosphoprotein Protein transport Proteomics identification Reference proteome Translocation Transmembrane Transmembrane helix Transport Zellweger syndrome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	PEX14
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9001349] ENSEMBL:ENSG00000142655 PEX14 [Homo sapiens]
secondaryIdentifier	PEX14_HUMAN B2R7N1 B3KML6 B7Z1N2 Q8WX51
sequenceLength	377
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:423871] UniProt:O75381-1 PEX14 [Homo sapiens] [ReferenceIsoform:423872] UniProt:O75381-2 PEX14 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:9033101] PEX14 [peroxisomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:9603806] PEX14 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O75381 PEX14 (61554)