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Details on Person UniProt:P28328 PEX2
| Class:Id | ReferenceGeneProduct:61538 |
|---|---|
| _chainChangeLog | chain:1-305 added on Fri February 6 2015 |
| _displayName | UniProt:P28328 PEX2 |
| _timestamp | 2024-11-03 19:53:09 |
| chain | chain:1-305 |
| checksum | F624F93C613FF2DB |
| comment | FUNCTION E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (PubMed:27597759). Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed:34903883).CATALYTIC ACTIVITY [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.INTERACTION The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore (By similarity). The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex (By similarity).PTM Forms intramolecular and intermolecular disulfide bonds in response to reactive oxygen species (ROS), promoting higher stability.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the pex2/pex10/pex12 family. |
| description | recommendedName: fullName evidence="20"Peroxisome biogenesis factor 2 ecNumber evidence="16"2.3.2.27 ecNumber evidence="2"2.3.2.36 alternativeName: fullName evidence="18"35 kDa peroxisomal membrane protein alternativeName: fullName evidence="20"Peroxin-2 alternativeName: Peroxisomal membrane protein 3 alternativeName: fullName evidence="19"Peroxisome assembly factor 1 shortName evidence="19"PAF-1 alternativeName: RING finger protein 72 |
| geneName | PEX2 PAF1 PMP3 PMP35 PXMP3 RNF72 |
| identifier | P28328 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Disease variant Disulfide bond Membrane Metal-binding Peroxisome Peroxisome biogenesis Peroxisome biogenesis disorder Protein transport Proteomics identification Reference proteome Transferase Transmembrane Transmembrane helix Transport Ubl conjugation pathway Zellweger syndrome Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PEX2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990306] ENSEMBL:ENSG00000164751 PEX2 [Homo sapiens] |
| secondaryIdentifier | PEX2_HUMAN Q567S6 Q9BW41 |
| sequenceLength | 305 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8953913] PEX2 [peroxisomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:9625570] PEX2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P28328 PEX2 (61538)
