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Details on Person UniProt:P16284 PECAM1

Class:Id	ReferenceGeneProduct:61490
_chainChangeLog	signal peptide:1-27 added on Fri February 6 2015;chain:28-738 added on Fri February 6 2015
_displayName	UniProt:P16284 PECAM1
_timestamp	2024-11-03 19:42:37
chain	signal peptide:1-27 chain:28-738
checksum	9D531D2DDCCB7F92
comment	FUNCTION Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity).FUNCTION Does not protect against apoptosis.SUBUNIT Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction (PubMed:26702061, PubMed:27958302). Forms a complex with BDKRB2 and GNAQ (PubMed:18672896). Interacts with BDKRB2 and GNAQ (PubMed:18672896). Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment (PubMed:18388311, PubMed:19342684). Interacts with FER (By similarity). Interacts (via Ig-like C2-type domain 6) with CD177; the interaction is Ca(2+)-dependent; the interaction is direct (PubMed:17580308).INTERACTION Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.SUBCELLULAR LOCATION Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.SUBCELLULAR LOCATION Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.ALTERNATIVE PRODUCTS Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:17580308, PubMed:19342684). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).DOMAIN The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity.PTM Phosphorylated on Ser and Tyr residues after cellular activation by src kinases (PubMed:18710921, PubMed:19342684, PubMed:21464369, PubMed:9298995). Upon activation, phosphorylated on Ser-729 which probably initiates the dissociation of the membrane-interaction segment (residues 709-729) from the cell membrane allowing the sequential phosphorylation of Tyr-713 and Tyr-690 (PubMed:21464369). Constitutively phosphorylated on Ser-734 in resting platelets (PubMed:21464369). Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation (PubMed:18710921).PTM Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.ONLINE INFORMATION CD31 entryONLINE INFORMATION PECAM-1
description	recommendedName: Platelet endothelial cell adhesion molecule shortName: PECAM-1 alternativeName: EndoCAM alternativeName: GPIIA' alternativeName: PECA1 cdAntigenNameCD31/cdAntigenName
geneName	PECAM1
identifier	P16284
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cell adhesion Cell junction Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Lipoprotein Membrane Palmitate Phagocytosis Phosphoprotein Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	PECAM1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9607578] ENSEMBL:ENSG00000261371 PECAM1 [Homo sapiens]
secondaryIdentifier	PECA1_HUMAN A0A075B738 A8K3S7 D3DU31 Q6LDA9 Q8TBH1 Q96RF5 Q96RF6 Q9NP65 Q9NPB7 Q9NPG9 Q9NQS9 Q9NQT0 Q9NQT1 Q9NQT2
sequenceLength	738
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:151954] UniProt:P16284-2 PECAM1 [Homo sapiens] [ReferenceIsoform:151955] UniProt:P16284-3 PECAM1 [Homo sapiens] [ReferenceIsoform:151956] UniProt:P16284-4 PECAM1 [Homo sapiens] [ReferenceIsoform:151957] UniProt:P16284-5 PECAM1 [Homo sapiens] [ReferenceIsoform:151958] UniProt:P16284-6 PECAM1 [Homo sapiens] [ReferenceIsoform:403036] UniProt:P16284-1 PECAM1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:61489] PECAM1 [platelet alpha granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:114686] PECAM1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:210007] p-Y663,Y686-PECAM1(27-?) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6804778] PECAM1 [secretory granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:9860772] p-Y713-PECAM1 [plasma membrane] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:210018] O4'-phospho-L-tyrosine at 686 [ModifiedResidue:210025] O4'-phospho-L-tyrosine at 663 [ModifiedResidue:9860820] O4'-phospho-L-tyrosine at 713
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No pathways have been reviewed or authored by UniProt:P16284 PECAM1 (61490)