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Details on Person UniProt:Q15120 PDK3
| Class:Id | ReferenceGeneProduct:61450 |
|---|---|
| _chainChangeLog | transit peptide:1- added on Fri February 6 2015;chain:-406 added on Fri February 6 2015 |
| _displayName | UniProt:Q15120 PDK3 |
| _timestamp | 2025-02-21 18:40:18 |
| chain | transit peptide:1- chain:-406 |
| checksum | EF2415D3F9D8D61E |
| comment | FUNCTION Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.CATALYTIC ACTIVITY L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)ACTIVITY REGULATION Activated by interaction with DLAT. Inhibited by AZD7545, dichloroacetate and radicicol.SUBUNIT Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).INTERACTION Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain.INDUCTION Up-regulated in response to hypoxia. Up-regulated in response to fatty acids. Up-regulated by PPARD.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the PDK/BCKDK protein kinase family. |
| description | recommendedName: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial ecNumber: 2.7.11.2 alternativeName: Pyruvate dehydrogenase kinase isoform 3 |
| geneName | PDK3 PDHK3 |
| identifier | Q15120 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Charcot-Marie-Tooth disease Disease variant Kinase Mitochondrion Neurodegeneration Neuropathy Nucleotide-binding Proteomics identification Reference proteome Transferase Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PDK3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999079] ENSEMBL:ENSG00000067992 PDK3 [Homo sapiens] |
| secondaryIdentifier | PDK3_HUMAN B4DXG6 |
| sequenceLength | 406 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8964920] UniProt:Q15120-1 PDK3 [Homo sapiens] [ReferenceIsoform:8964921] UniProt:Q15120-2 PDK3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:203940] PDK3(?-406) [mitochondrial matrix] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q15120 PDK3 (61450)
