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Details on Person UniProt:P01127 PDGFB
| Class:Id | ReferenceGeneProduct:61434 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Fri February 6 2015;propeptide:21-81 added on Fri February 6 2015;chain:82-190 added on Fri February 6 2015;propeptide:191-241 added on Fri February 6 2015 |
| _displayName | UniProt:P01127 PDGFB |
| _timestamp | 2024-11-03 20:15:54 |
| chain | signal peptide:1-20 propeptide:21-81 chain:82-190 propeptide:191-241 |
| checksum | 9F9A3474CE203C0B |
| comment | FUNCTION Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).SUBUNIT Antiparallel homodimer; disulfide-linked. Antiparallel heterodimer with PDGFA; disulfide-linked. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity). Interacts with LRP1 (PubMed:15053742). Interacts with SORL1 (via the N-terminal ectodomain) (PubMed:15053742, PubMed:16393139). Interacts with CD82; this interaction inhibits PDGFB-mediated signaling pathway (PubMed:34530889).INTERACTION Released by platelets upon wounding.ALTERNATIVE PRODUCTS Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.PHARMACEUTICAL Available under the name Regranex (Ortho-McNeil). Used to promote healing in diabetic neuropathic foot ulcers.SIMILARITY Belongs to the PDGF/VEGF growth factor family. |
| description | recommendedName: Platelet-derived growth factor subunit B shortName: PDGF subunit B alternativeName: PDGF-2 alternativeName: Platelet-derived growth factor B chain alternativeName: Platelet-derived growth factor beta polypeptide alternativeName: Proto-oncogene c-Sis innNameBecaplermin/innName |
| geneName | PDGFB PDGF2 SIS |
| identifier | P01127 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative promoter usage Chromosomal rearrangement Cleavage on pair of basic residues Developmental protein Direct protein sequencing Disease variant Disulfide bond Glycoprotein Growth factor Mitogen Pharmaceutical Proteomics identification Proto-oncogene Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PDGFB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999676] ENSEMBL:ENSG00000100311 PDGFB [Homo sapiens] |
| secondaryIdentifier | PDGFB_HUMAN G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 |
| sequenceLength | 241 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970663] UniProt:P01127-1 PDGFB [Homo sapiens] [ReferenceIsoform:8970664] UniProt:P01127-2 PDGFB [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:61433] PDGFB [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:139871] PDGFB [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:184200] PDGFB(21-81) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:184201] PDGFB (82-190) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:380740] PDGFB(1-241) [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:381903] PDGFB(1-241) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:381904] PDGFB(82-241) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:387075] PDGFB(82-241) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:389058] PDGFB(1-81) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:396945] PDGFB(191-241) [Golgi lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P01127 PDGFB (61434)
