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Details on Person UniProt:P04085-1 PDGFA
| Class:Id | ReferenceIsoform:61432 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Sat February 7 2015;propeptide:21-86 added on Sat February 7 2015;chain:87-211 added on Sat February 7 2015 |
| _displayName | UniProt:P04085-1 PDGFA |
| _timestamp | 2024-11-03 19:47:51 |
| chain | signal peptide:1-20 propeptide:21-86 chain:87-211 |
| checksum | 48633DDE558EFA43 |
| comment | FUNCTION Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).SUBUNIT Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.INTERACTION Released by platelets upon wounding.ALTERNATIVE PRODUCTS The long form contains a basic insert which acts as a cell retention signal.SIMILARITY Belongs to the PDGF/VEGF growth factor family. |
| description | recommendedName: Platelet-derived growth factor subunit A shortName: PDGF subunit A alternativeName: PDGF-1 alternativeName: Platelet-derived growth factor A chain alternativeName: Platelet-derived growth factor alpha polypeptide |
| geneName | PDGFA PDGF1 |
| identifier | P04085 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cleavage on pair of basic residues Developmental protein Disulfide bond Glycoprotein Growth factor Mitogen Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PDGFA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990305] ENSEMBL:ENSG00000197461 PDGFA [Homo sapiens] |
| secondaryIdentifier | PDGFA_HUMAN B5BU73 |
| sequenceLength | 211 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P04085-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:61431] PDGFA-1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:139870] PDGFA-1(1-211) [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:184199] PDGFA-1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:184205] PDGFA-1 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:380743] PDGFA-1(1-211) [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:381910] PDGFA-1(1-211) [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8865268] N-ter PDGFA-1 fragment [Golgi lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P04085-1 PDGFA (61432)
