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Details on Person UniProt:Q92824 PCSK5
| Class:Id | ReferenceGeneProduct:61396 |
|---|---|
| _chainChangeLog | signal peptide:1-32 added on Sat February 7 2015;propeptide:33-114 added on Sat February 7 2015;chain:115-1860 added on Sat February 7 2015 |
| _displayName | UniProt:Q92824 PCSK5 |
| _timestamp | 2024-11-03 20:02:23 |
| chain | signal peptide:1-32 propeptide:33-114 chain:115-1860 |
| checksum | 96B3E7C8215BCC85 |
| comment | FUNCTION Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.INTERACTION Secreted through the regulated secretory pathway.SUBCELLULAR LOCATION Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.ALTERNATIVE PRODUCTS Expressed in T-lymphocytes.DOMAIN The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.DOMAIN AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1 (By similarity).SIMILARITY Belongs to the peptidase S8 family. |
| description | recommendedName: Proprotein convertase subtilisin/kexin type 5 ecNumber: 3.4.21.- alternativeName: Proprotein convertase 5 shortName: PC5 alternativeName: Proprotein convertase 6 shortName: PC6 shortName: hPC6 alternativeName: Subtilisin/kexin-like protease PC5 |
| geneName | PCSK5 PC5 PC6 |
| identifier | Q92824 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cleavage on pair of basic residues Glycoprotein Hydrolase Membrane Pregnancy Protease Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Transmembrane Transmembrane helix Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PCSK5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993805] ENSEMBL:ENSG00000099139 PCSK5 [Homo sapiens] |
| secondaryIdentifier | PCSK5_HUMAN F5H2G7 Q13527 Q96EP4 |
| sequenceLength | 1860 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:412497] UniProt:Q92824-1 PCSK5 [Homo sapiens] [ReferenceIsoform:8969359] UniProt:Q92824-2 PCSK5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:166558] PCSK5(115-1860) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:6784682] PCSK5 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q92824 PCSK5 (61396)
