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Details on Person UniProt:P43490 NAMPT
| Class:Id | ReferenceGeneProduct:61352 |
|---|---|
| _chainChangeLog | chain:1-491 added on Fri February 6 2015 |
| _displayName | UniProt:P43490 NAMPT |
| _timestamp | 2025-02-21 19:30:06 |
| chain | chain:1-491 |
| checksum | 6BF07B631B589AC0 |
| comment | FUNCTION Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).CATALYTIC ACTIVITY beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+)ACTIVITY REGULATION Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its very low dissociation rate, it is essentially an irreversible inhibitor.PATHWAY Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.SUBUNIT Homodimer.INTERACTION Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.TISSUE SPECIFICITY Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.SIMILARITY Belongs to the NAPRTase family. |
| description | recommendedName: Nicotinamide phosphoribosyltransferase shortName: NAmPRTase shortName: Nampt ecNumber evidence="1"2.4.2.12 alternativeName: Pre-B-cell colony-enhancing factor 1 shortName: Pre-B cell-enhancing factor alternativeName: Visfatin |
| geneName | NAMPT PBEF PBEF1 |
| identifier | P43490 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Biological rhythms Cytokine Cytoplasm Glycosyltransferase Nucleus Phosphoprotein Proteomics identification Pyridine nucleotide biosynthesis Reference proteome Secreted Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | NAMPT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5641207] ENSEMBL:ENSG00000105835 NAMPT [Homo sapiens] |
| secondaryIdentifier | NAMPT_HUMAN A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 |
| sequenceLength | 491 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:197188] NAMPT [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8957600] NAMPT [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9961799] NAMPT [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P43490 NAMPT (61352)
