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Details on Person UniProt:Q9DAN9 Cfap97d1
| Class:Id | ReferenceGeneProduct:613459 |
|---|---|
| _chainChangeLog | chain:1-164 added on Sat February 7 2015 |
| _displayName | UniProt:Q9DAN9 Cfap97d1 |
| _timestamp | 2023-11-03 16:19:22 |
| chain | chain:1-164 |
| checksum | EC5236AEB236BDE0 |
| comment | FUNCTION Required for male fertility through its role in axonemal doublet stabilization which is essential for sperm motility and fertilization.TISSUE SPECIFICITY Expressed exclusively in testis.DEVELOPMENTAL STAGE Expression starts at postnatal day 20 and continues throughout adulthood.DISRUPTION PHENOTYPE Male subfertility. Sperm show an impaired ability to penetrate the zona pellucida and abnormal motility characterized by frequent stalling in the anti-hook position with the flagellum and hook of the sperm head pointing in opposite directions. Sperm flagella lack outer microtubule doublet 4 in 63% of mutants while doublet 7 is missing in 14.8% of mutants. A small number of mutants have multiple doublets missing but these are relatively rare: the 4th and 7th doublets are missing in 1.6% of mutants; the 4th, 5th and 7th doublets are missing in 3.7%; the 4th, 5th and 6th doublets are missing in 1.23%; and the 4th, 5th, 6th and 7th doublets are missing in 1.23%.SIMILARITY Belongs to the CFAP97 family. |
| created | [InstanceEdit:613449] Kanapin, AA |
| description | recommendedName: fullName evidence="3"Sperm axonemal maintenance protein CFAP97D1 alternativeName: CFAP97 domain-containing protein 1 |
| geneName | Cfap97d1 |
| identifier | Q9DAN9 |
| isSequenceChanged | FALSE |
| keyword | Coiled coil Reference proteome |
| modified | [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6791590] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Cfap97d1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CF97D_MOUSE |
| sequenceLength | 164 |
| species | [Species:48892] Mus musculus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9DAN9 Cfap97d1 (613459)
