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Details on Person UniProt:Q3UD01 Atxn7l3b
| Class:Id | ReferenceGeneProduct:613458 |
|---|---|
| _chainChangeLog | chain:1-97 added on Fri February 6 2015 |
| _displayName | UniProt:Q3UD01 Atxn7l3b |
| _timestamp | 2023-11-03 17:36:43 |
| chain | chain:1-97 |
| checksum | 6E4A40700ECFA57D |
| comment | FUNCTION By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.SUBUNIT Interacts strongly with ENY2. Interacts weakly with USP22.SUBCELLULAR LOCATION Encoded by an expressed retrotransposed copy of the Atxn7l3 locus that emerged prior to the speciation event separating primates and rodents.SIMILARITY Belongs to the SGF11 family. |
| created | [InstanceEdit:613449] Kanapin, AA |
| description | recommendedName: Ataxin-7-like protein 3B |
| geneName | Atxn7l3b |
| identifier | Q3UD01 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Phosphoprotein Reference proteome |
| modified | [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Atxn7l3b |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | A7L3B_MOUSE |
| sequenceLength | 97 |
| species | [Species:48892] Mus musculus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q3UD01 Atxn7l3b (613458)
