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Details on Person UniProt:A7MAZ3 UBA5
| Class:Id | ReferenceGeneProduct:613457 |
|---|---|
| _chainChangeLog | chain:1-404 added on Sat February 7 2015 |
| _displayName | UniProt:A7MAZ3 UBA5 |
| _timestamp | 2024-08-09 19:44:47 |
| chain | chain:1-404 |
| checksum | F1FD2BB9A5D1BC6B |
| comment | FUNCTION E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity).SUBUNIT Homodimer; homodimerization is required for UFM1 activation. Interacts (via UIS motif) with UFM1; binds UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Interacts (via C-terminus) with UFC1. Interacts (via UIS motif) with GABARAPL2 and, with lower affinity, with GABARAP and GABARAPL1.SUBCELLULAR LOCATION Localizes mainly in the cytoplasm, while it localizes to the nucleus in presence of SUMO2. Interaction with GABARAPL2 promotes localization to the endoplasmic reticulum membrane.DOMAIN The UFC1-binding sequence (UFC) motif mediates interaction with UFC1.DOMAIN The linker region is required to activate the active site of UFC1: it region moves next to active site of UFC1 to reduce the amount of water molecules in the vicinity of UFC1's active site and thereby elevate the nucleophilic activity of UFC1 active site.DOMAIN The UFM1-interacting sequence (UIS) motif mediates interaction with both UFM1 and LC3/GABARAP proteins (GABARAP, GABARAPL1 and GABARAPL2).SIMILARITY Belongs to the ubiquitin-activating E1 family. UBA5 subfamily. |
| created | [InstanceEdit:613449] Kanapin, AA |
| description | recommendedName: fullName evidence="3"Ubiquitin-like modifier-activating enzyme 5 shortName evidence="2"Ubiquitin-activating enzyme 5 alternativeName: fullName evidence="3"UFM1-activating enzyme |
| geneName | UBA5 |
| identifier | A7MAZ3 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cytoplasm Endoplasmic reticulum Golgi apparatus Membrane Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Ubl conjugation pathway Zinc |
| modified | [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | UBA5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | UBA5_BOVIN |
| sequenceLength | 404 |
| species | [Species:48898] Bos taurus |
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No pathways have been reviewed or authored by UniProt:A7MAZ3 UBA5 (613457)
