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Details on Person UniProt:C8ZFZ7-1 LAP3
| Class:Id | ReferenceIsoform:613452 |
|---|---|
| _chainChangeLog | transit peptide:1-30 added on Sat February 7 2015;chain:31-482 added on Sat February 7 2015;propeptide:- added on Sat February 7 2015 |
| _displayName | UniProt:C8ZFZ7-1 LAP3 |
| _timestamp | 2023-11-03 15:00:21 |
| chain | transit peptide:1-30 chain:31-482 propeptide:- |
| checksum | BF92A6049F98DD3D |
| comment | FUNCTION The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities (By similarity).CATALYTIC ACTIVITY Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.ACTIVITY REGULATION Inhibited by E64, a specific inhibitor of cysteine proteases, N-ethylmaleimide, iodacetamide, and mercury and zinc ions.SUBUNIT Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA (By similarity).SUBCELLULAR LOCATION The N-terminus of isoform Cytoplasmic is blocked.SIMILARITY Belongs to the peptidase C1 family. |
| created | [InstanceEdit:613449] Kanapin, AA |
| description | recommendedName: Cysteine proteinase 1, mitochondrial ecNumber: 3.4.22.40 alternativeName: Bleomycin hydrolase shortName: BLM hydrolase alternativeName: Homocysteine-thiolactonase shortName: HTLase shortName: Hcy-thiolactonase alternativeName: Leucine aminopeptidase 3 alternativeName: Y3 |
| geneName | LAP3 BLH1 GAL6 YCP1 EC1118_1N9_1035g |
| identifier | C8ZFZ7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative initiation Cytoplasm DNA-binding Hydrolase Mitochondrion Protease Thiol protease Transit peptide |
| modified | [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | LAP3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | BLH1_YEAS8 |
| sequenceLength | 483 |
| species | [Species:68322] Saccharomyces cerevisiae |
| variantIdentifier | C8ZFZ7-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:C8ZFZ7-1 LAP3 (613452)
