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Details on Person UniProt:Q9HBI1 PARVB
| Class:Id | ReferenceGeneProduct:61320 |
|---|---|
| _chainChangeLog | chain:1-364 added on Sat February 7 2015 |
| _displayName | UniProt:Q9HBI1 PARVB |
| _timestamp | 2024-11-03 20:15:51 |
| chain | chain:1-364 |
| checksum | 4BA4B50C83083DC7 |
| comment | FUNCTION Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.SUBUNIT Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin.INTERACTION Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.ALTERNATIVE PRODUCTS Expressed predominantly in heart and skeletal muscle.SIMILARITY Belongs to the parvin family. |
| description | recommendedName: Beta-parvin alternativeName: Affixin |
| geneName | PARVB CGI-56 |
| identifier | Q9HBI1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Actin-binding Alternative splicing Cell adhesion Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Membrane Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PARVB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997340] ENSEMBL:ENSG00000188677 PARVB [Homo sapiens] |
| secondaryIdentifier | PARVB_HUMAN B0QYM8 B0QYN1 B2R9X6 Q5TGJ5 Q86X93 Q96PN1 Q9NSP7 Q9UGT3 Q9Y368 Q9Y3L6 Q9Y3L7 |
| sequenceLength | 364 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971114] UniProt:Q9HBI1-1 PARVB [Homo sapiens] [ReferenceIsoform:8971115] UniProt:Q9HBI1-2 PARVB [Homo sapiens] [ReferenceIsoform:8971116] UniProt:Q9HBI1-3 PARVB [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:446016] PARVB [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9HBI1 PARVB (61320)
