Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q96RI0 F2RL3
| Class:Id | ReferenceGeneProduct:61316 |
|---|---|
| _chainChangeLog | signal peptide:1-17 added on Fri February 6 2015;propeptide:18-47 added on Fri February 6 2015;chain:48-385 added on Fri February 6 2015 |
| _displayName | UniProt:Q96RI0 F2RL3 |
| _timestamp | 2024-11-03 19:42:31 |
| chain | signal peptide:1-17 propeptide:18-47 chain:48-385 |
| checksum | FACE32F10D5C561E |
| comment | FUNCTION Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109).ACTIVITY REGULATION Activated upon interaction by mucunain, a cowhage (Mucuna pruriens) plant cysteine proteinase.SUBCELLULAR LOCATION Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.PTM A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: Proteinase-activated receptor 4 shortName: PAR-4 alternativeName: Coagulation factor II receptor-like 3 alternativeName: Thrombin receptor-like 3 |
| geneName | F2RL3 PAR4 |
| identifier | Q96RI0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Blood coagulation Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Hemostasis Membrane Proteomics identification Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | F2RL3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996178] ENSEMBL:ENSG00000127533 F2RL3 [Homo sapiens] |
| secondaryIdentifier | PAR4_HUMAN O76067 Q6DK42 |
| sequenceLength | 385 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:61315] F2RL3(18-385) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:114533] F2RL3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:114589] F2RL3(18-47) [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96RI0 F2RL3 (61316)
