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Details on Person UniProt:O00254 F2RL2
| Class:Id | ReferenceGeneProduct:61314 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Sat February 7 2015;propeptide:22-38 added on Sat February 7 2015;chain:39-374 added on Sat February 7 2015 |
| _displayName | UniProt:O00254 F2RL2 |
| _timestamp | 2024-11-03 19:42:31 |
| chain | signal peptide:1-21 propeptide:22-38 chain:39-374 |
| checksum | C45C15A695DD1ABB |
| comment | FUNCTION Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.SUBUNIT Interacts with INSC/inscuteable and probably GPSM2.INTERACTION Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.PTM A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: Proteinase-activated receptor 3 shortName: PAR-3 alternativeName: Coagulation factor II receptor-like 2 alternativeName: Thrombin receptor-like 2 |
| geneName | F2RL2 PAR3 |
| identifier | O00254 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Blood coagulation Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Hemostasis Membrane Proteomics identification Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | F2RL2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989714] ENSEMBL:ENSG00000164220 F2RL2 [Homo sapiens] |
| secondaryIdentifier | PAR3_HUMAN B2R754 B4DQ13 Q52M68 Q7Z3W3 |
| sequenceLength | 374 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977530] UniProt:O00254-1 F2RL2 [Homo sapiens] [ReferenceIsoform:8977531] UniProt:O00254-2 F2RL2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:61313] F2RL2(22-374) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:114532] F2RL2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:114588] F2RL2(22-38) [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O00254 F2RL2 (61314)
