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Details on Person UniProt:Q96RD6 PANX2
| Class:Id | ReferenceGeneProduct:61296 |
|---|---|
| _chainChangeLog | chain:1-677 added on Fri February 6 2015 |
| _displayName | UniProt:Q96RD6 PANX2 |
| _timestamp | 2024-11-03 20:11:14 |
| chain | chain:1-677 |
| checksum | E15C741192B1BD46 |
| comment | FUNCTION Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity).CATALYTIC ACTIVITY ATP(in) = ATP(out)CATALYTIC ACTIVITY chloride(in) = chloride(out)CATALYTIC ACTIVITY iodide(out) = iodide(in)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY D-gluconate(in) = D-gluconate(out)SUBUNIT Homoheptameric.SUBCELLULAR LOCATION Localizes to Golgi apparatus and endoplasmic reticulum in multipotential neural stem and progenitor cells and to plasma membrane in terminally differentiated neurons.ALTERNATIVE PRODUCTS S-palmitoylated in neural stem and progenitor cells.PTM Cleaved by CASP3 and CASP7 during apoptosis. Cleavage has no effect on it function.SIMILARITY Belongs to the pannexin family.ONLINE INFORMATION Pannexin entry |
| description | recommendedName: Pannexin-2 |
| geneName | PANX2 |
| identifier | Q96RD6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Endoplasmic reticulum Glycoprotein Golgi apparatus Ion channel Ion transport Membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PANX2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991461] ENSEMBL:ENSG00000073150 PANX2 [Homo sapiens] |
| secondaryIdentifier | PANX2_HUMAN B7Z684 Q96RD5 Q9UGX8 |
| sequenceLength | 677 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:151752] UniProt:Q96RD6-2 PANX2 [Homo sapiens] [ReferenceIsoform:413060] UniProt:Q96RD6-1 PANX2 [Homo sapiens] [ReferenceIsoform:8965282] UniProt:Q96RD6-3 PANX2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:375350] PANX2 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96RD6 PANX2 (61296)
