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Details on Person UniProt:Q9NQU5 PAK6
| Class:Id | ReferenceGeneProduct:61284 |
|---|---|
| _chainChangeLog | chain:1-681 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NQU5 PAK6 |
| _timestamp | 2025-05-21 21:32:08 |
| chain | chain:1-681 |
| checksum | F20A4FA257649BB9 |
| comment | FUNCTION Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.INTERACTION Cotranslocates into nucleus with AR in response to androgen induction.ALTERNATIVE PRODUCTS Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.PTM Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.SIMILARITY Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. |
| description | recommendedName: Serine/threonine-protein kinase PAK 6 ecNumber: 2.7.11.1 alternativeName: PAK-5 alternativeName: p21-activated kinase 6 shortName: PAK-6 |
| geneName | PAK6 PAK5 |
| identifier | Q9NQU5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cytoplasm Kinase Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | PAK6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997339] ENSEMBL:ENSG00000137843 PAK6 [Homo sapiens] |
| secondaryIdentifier | PAK6_HUMAN A8K2G2 B3KYB0 G5E9R2 |
| sequenceLength | 681 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971111] UniProt:Q9NQU5-1 PAK6 [Homo sapiens] [ReferenceIsoform:8971112] UniProt:Q9NQU5-2 PAK6 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:428454] PAK6 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NQU5 PAK6 (61284)
