Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P05121 SERPINE1
| Class:Id | ReferenceGeneProduct:61272 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-402 added on Fri February 6 2015 |
| _displayName | UniProt:P05121 SERPINE1 |
| _timestamp | 2025-05-21 21:20:11 |
| chain | signal peptide:1-23 chain:24-402 |
| checksum | A2E181ED28DD6082 |
| comment | FUNCTION Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:17912461, PubMed:8481516, PubMed:9207454, PubMed:21925150). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).SUBUNIT Forms a heterodimer with TMPRSS7 (PubMed:15853774). Interacts with VTN (PubMed:7522053). Binds LRP1B; binding is followed by internalization and degradation (PubMed:11384978). Interacts with PPP1CB (PubMed:28296156). In complex with PLAU/uPA, interacts with PLAUR/uPAR (PubMed:15053742). Interacts with SORL1 and LRP1, either alone or in complex with PLAU; these interactions are abolished in the presence of LRPAP1/RAP (PubMed:15053742). The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORL1 (PubMed:15053742). Interacts with PLAT/tPA (PubMed:21925150). Also interacts with SORL1, when complexed to PLAT/tPA (PubMed:15053742).INTERACTION Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.INDUCTION Up-regulated by coagulation factor Xa (F10) in atrial tissues (PubMed:24041930). Up-regulated in atrial tissues by rapid pacing resembling atrial fibrillation (PubMed:24041930).PTM Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.DISEASE The disease is caused by variants affecting the gene represented in this entry. A rare PAI-1D mutation resulting in a frameshift and protein truncation has been found in an Old Order Amish community. Homozygous mutation carriers suffer from episodes of major hemorrhage, while heterozygous carriers do not manifest abnormal bleeding (PubMed:9207454). Heterozygosity for the mutation is associated with longer leukocyte telomere length, lower fasting insulin levels, lower prevalence of diabetes mellitus, and a longer life span (PubMed:29152572).SIMILARITY Belongs to the serpin family.ONLINE INFORMATION Plasminogen activator inhibitor-1 entryONLINE INFORMATION Giving in to time - Issue 203 of May 2018 |
| description | recommendedName: Plasminogen activator inhibitor 1 shortName: PAI shortName: PAI-1 alternativeName: Endothelial plasminogen activator inhibitor alternativeName: Serpin E1 |
| geneName | SERPINE1 PAI1 PLANH1 |
| identifier | P05121 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Direct protein sequencing Glycoprotein Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | SERPINE1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2106585] ENSEMBL:ENSG00000106366 SERPINE1 [Homo sapiens] |
| secondaryIdentifier | PAI1_HUMAN B7Z4S0 F8WD53 |
| sequenceLength | 402 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8967956] UniProt:P05121-1 SERPINE1 [Homo sapiens] [ReferenceIsoform:8967957] UniProt:P05121-2 SERPINE1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:114649] SERPINE1 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:158797] SERPINE1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158922] SERPINE1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P05121 SERPINE1 (61272)
