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Details on Person UniProt:O00459 PIK3R2
| Class:Id | ReferenceGeneProduct:61194 |
|---|---|
| _chainChangeLog | chain:1-728 added on Fri February 6 2015 |
| _displayName | UniProt:O00459 PIK3R2 |
| _timestamp | 2025-08-15 21:47:30 |
| chain | chain:1-728 |
| checksum | ADAC3E4B61F3F44A |
| comment | FUNCTION Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).SUBUNIT Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD) (PubMed:23604317). Interacts with AXL (PubMed:9178760). Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated) (PubMed:15102829, PubMed:9600074). Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex (PubMed:23604317). Interacts with PTPN13; dephosphorylates PIK3R2 (PubMed:23604317). Interacts with XBP1 isoform 2; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus in a ER stress- and/or insulin-dependent but PI3K-independent manner (By similarity). Interacts with PIK3R1; the interaction is dissociated in an insulin-dependent manner (By similarity). Interacts with SRC (PubMed:28903391).INTERACTION The SH2 2 domain is required for interaction with FBXL2 and PTPN13.PTM Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).PTM Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the PI3K p85 subunit family. |
| description | recommendedName: Phosphatidylinositol 3-kinase regulatory subunit beta shortName: PI3-kinase regulatory subunit beta shortName: PI3K regulatory subunit beta shortName: PtdIns-3-kinase regulatory subunit beta alternativeName: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta shortName: PI3-kinase subunit p85-beta shortName: PtdIns-3-kinase regulatory subunit p85-beta |
| geneName | PIK3R2 |
| identifier | O00459 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant GTPase activation Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat SH2 domain SH3 domain Stress response Transport Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PIK3R2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995595] ENSEMBL:ENSG00000105647 PIK3R2 [Homo sapiens] |
| secondaryIdentifier | P85B_HUMAN Q5EAT5 Q9UPH9 |
| sequenceLength | 728 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:74791] PIK3R2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3080554] K63polyUb-PIK3R2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9860512] p-Y464-PIK3R2 [cytosol] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:3080566] ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position [ModifiedResidue:9860492] O4'-phospho-L-tyrosine at 464 |
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No pathways have been reviewed or authored by UniProt:O00459 PIK3R2 (61194)
