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Details on Person UniProt:Q96G91 P2RY11
| Class:Id | ReferenceGeneProduct:61156 |
|---|---|
| _chainChangeLog | chain:1-374 added on Sat February 7 2015 |
| _displayName | UniProt:Q96G91 P2RY11 |
| _timestamp | 2024-08-09 19:59:58 |
| chain | chain:1-374 |
| checksum | C02DF9B3B381D25E |
| comment | FUNCTION Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.SUBCELLULAR LOCATION Highest expression in liver and spleen.INDUCTION Increased by DMSO and retinoic acid.MISCELLANEOUS A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: P2Y purinoceptor 11 shortName: P2Y11 |
| geneName | P2RY11 |
| identifier | Q96G91 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | P2RY11 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992645] ENSEMBL:ENSG00000244165 P2RY11 [Homo sapiens] |
| secondaryIdentifier | P2Y11_HUMAN B2R8X9 O43190 Q9BYU4 Q9H170 |
| sequenceLength | 374 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:417837] P2RY11 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96G91 P2RY11 (61156)
