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Details on Person UniProt:P51575 P2RX1
| Class:Id | ReferenceGeneProduct:61130 |
|---|---|
| _chainChangeLog | chain:1-399 added on Sat February 7 2015 |
| _displayName | UniProt:P51575 P2RX1 |
| _timestamp | 2025-02-21 20:12:39 |
| chain | chain:1-399 |
| checksum | 8365466665522BF8 |
| comment | FUNCTION ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (PubMed:10440098, PubMed:15056721, PubMed:20699225, PubMed:8834001, PubMed:8961184). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (PubMed:14699168). Plays a role a role in urogenital, immune and cardiovascular function (By similarity). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (By similarity). In addition, contributes to smooth muscle contractions of the urinary bladder (By similarity). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (By similarity). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)ACTIVITY REGULATION Activated by low concentrations of ATP (<1 uM) (PubMed:10440098, PubMed:8834001). Undergoes rapid desensitisation (PubMed:10440098). Sensitives to the ATP agonist:alpha/beta-methylene-ATP (PubMed:19635923, PubMed:8834001). Modulated by cholesterol (PubMed:20699225).SUBUNIT Functional P2XRs are organized as homomeric and heteromeric trimers. Forms heterodimer with P2RX2. Forms heterodimer with P2RX4. Forms heterodimer with P2RX5.INTERACTION Detected at plasma membrane lipid rafts.TISSUE SPECIFICITY Expressed on neutrophils and platelets (PubMed:19635923). Expressed on urinary bladder smooth muscle (PubMed:8834001).DOMAIN The N-terminal 20 to 23 and 27 to 29 residues seem to play a role in the cholesterol-dependent gating of this receptor.SIMILARITY Belongs to the P2X receptor family.ONLINE INFORMATION P2X receptor entryONLINE INFORMATION P2RX1 entry |
| description | recommendedName: P2X purinoceptor 1 shortName: P2X1 alternativeName: ATP receptor alternativeName: Purinergic receptor |
| geneName | P2RX1 P2X1 |
| identifier | P51575 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Apoptosis ATP-binding Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Nucleotide-binding Phosphoprotein Proteomics identification Receptor Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | P2RX1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993210] ENSEMBL:ENSG00000108405 P2RX1 [Homo sapiens] |
| secondaryIdentifier | P2RX1_HUMAN Q9UK84 |
| sequenceLength | 399 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:61129] P2RX1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803317] P2RX1 [specific granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803326] P2RX1 [secretory granule membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P51575 P2RX1 (61130)
