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Details on Person UniProt:Q9BZF1 OSBPL8
| Class:Id | ReferenceGeneProduct:60996 |
|---|---|
| _chainChangeLog | chain:1-889 added on Sat February 7 2015 |
| _displayName | UniProt:Q9BZF1 OSBPL8 |
| _timestamp | 2024-11-03 19:57:33 |
| chain | chain:1-889 |
| checksum | 79DB8055BD15FE95 |
| comment | FUNCTION Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267).SUBUNIT Interacts with SPAG5 (PubMed:24424245). Interacts with NUP62 (PubMed:21698267).INTERACTION The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable).SUBCELLULAR LOCATION Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites.ALTERNATIVE PRODUCTS Widely expressed (PubMed:11735225). Expressed at higher level in macrophages (PubMed:17991739).SIMILARITY Belongs to the OSBP family. |
| description | recommendedName: Oxysterol-binding protein-related protein 8 shortName: ORP-8 shortName: OSBP-related protein 8 |
| geneName | OSBPL8 KIAA1451 ORP8 OSBP10 |
| identifier | Q9BZF1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Endoplasmic reticulum Lipid transport Lipid-binding Membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | OSBPL8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001326] ENSEMBL:ENSG00000091039 OSBPL8 [Homo sapiens] |
| secondaryIdentifier | OSBL8_HUMAN A8K1T2 E9PE66 E9PE68 Q52LQ3 Q68D75 Q8WXP8 Q9P277 |
| sequenceLength | 889 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:151555] UniProt:Q9BZF1-2 OSBPL8 [Homo sapiens] [ReferenceIsoform:413565] UniProt:Q9BZF1-1 OSBPL8 [Homo sapiens] [ReferenceIsoform:8968910] UniProt:Q9BZF1-3 OSBPL8 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8867870] OSBPL8 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BZF1 OSBPL8 (60996)
