Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9BXW6 OSBPL1A
| Class:Id | ReferenceGeneProduct:60984 |
|---|---|
| _chainChangeLog | chain:1-950 added on Fri February 6 2015 |
| _displayName | UniProt:Q9BXW6 OSBPL1A |
| _timestamp | 2024-11-03 19:53:00 |
| chain | chain:1-950 |
| checksum | CDDA26CA27B65F63 |
| comment | FUNCTION Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).SUBUNIT Interacts (via FFAT motif) with VAPA and VAPB (PubMed:33124732). Interacts with the GTP-bound form of RAB7A (PubMed:17081983). Interacts with OAS1B (By similarity). Interacts (via FFAT motif) with MOSPD2 (via MSP domain) (PubMed:29858488, PubMed:33124732).INTERACTION Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.ALTERNATIVE PRODUCTS The FFAT motif is required for interaction with MOSPD2, VAPA and VAPB.SIMILARITY Belongs to the OSBP family.SEQUENCE CAUTION Unlikely isoform. Aberrant splice sites. |
| description | recommendedName: fullName evidence="16"Oxysterol-binding protein-related protein 1 shortName: ORP-1 shortName: OSBP-related protein 1 |
| geneName | OSBPL1A ORP1 OSBP8 OSBPL1 OSBPL1B |
| identifier | Q9BXW6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ANK repeat Coiled coil Endosome Lipid transport Lipid-binding Phosphoprotein Proteomics identification Reference proteome Repeat Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | OSBPL1A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997332] ENSEMBL:ENSG00000141447 OSBPL1A [Homo sapiens] |
| secondaryIdentifier | OSBL1_HUMAN B7Z7D3 Q9BZF5 Q9NW87 |
| sequenceLength | 950 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:151541] UniProt:Q9BXW6-2 OSBPL1A [Homo sapiens] [ReferenceIsoform:413504] UniProt:Q9BXW6-1 OSBPL1A [Homo sapiens] [ReferenceIsoform:8974807] UniProt:Q9BXW6-4 OSBPL1A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:2213214] OSBPL1A [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BXW6 OSBPL1A (60984)
