Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person UniProt:P04000 OPN1LW

Class:IdReferenceGeneProduct:60962
_chainChangeLogchain:1-364 added on Fri February 6 2015
_displayNameUniProt:P04000 OPN1LW
_timestamp2025-05-21 21:51:04
chainchain:1-364
checksum730367A9CA3AB7D0
commentFUNCTION Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.BIOPHYSICOCHEMICAL PROPERTIES The three color pigments are found in the cone photoreceptor cells.PTM Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
descriptionrecommendedName: Long-wave-sensitive opsin 1 alternativeName: Red cone photoreceptor pigment alternativeName: Red-sensitive opsin shortName: ROP
geneNameOPN1LW
RCP
identifierP04000
isSequenceChangedFALSE
keyword3D-structure
Chromophore
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Photoreceptor protein
Receptor
Reference proteome
Retinal protein
Sensory transduction
Transducer
Transmembrane
Transmembrane helix
Vision
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
nameOPN1LW
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9001945] ENSEMBL:ENSG00000102076 OPN1LW [Homo sapiens]
secondaryIdentifierOPSR_HUMAN
sequenceLength364
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:419769] OPN1LW [photoreceptor disc membrane] [Homo sapiens]
[EntityWithAccessionedSequence:2471646] OPN1LW G338E [photoreceptor disc membrane] [Homo sapiens]
[EntityWithAccessionedSequence:2471668] OPN1LW R247* [photoreceptor disc membrane] [Homo sapiens]
[EntityWithAccessionedSequence:2471708] OPN1LW C203R [photoreceptor disc membrane] [Homo sapiens]
[EntityWithAccessionedSequence:2471740] OPN1LW P307L [photoreceptor disc membrane] [Homo sapiens]
[EntityWithAccessionedSequence:5211255] at-retinyl-OPN1LW [photoreceptor disc membrane] [Homo sapiens]
[EntityWithAccessionedSequence:5211266] 11cRAL-OPN1LW [photoreceptor disc membrane] [Homo sapiens]
(referenceSequence)[ReplacedResidue:2471666] L-proline 307 replaced with L-leucine
[NonsenseMutation:2471685] Nonsense mutation at L-arginine 247
[ReplacedResidue:2471700] glycine 338 replaced with L-glutamic acid
[ReplacedResidue:2471762] L-cysteine 203 replaced with L-arginine
[GroupModifiedResidue:5211256] atRAL-lysine (all-trans-retinyl group) at unknown position
[GroupModifiedResidue:5211264] N6-(11-cis)-retinylidene-L-lysine (11c-retinyl group) at unknown position
[Change default viewing format]
No pathways have been reviewed or authored by UniProt:P04000 OPN1LW (60962)