Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person UniProt:Q9UHM6 OPN4

Class:IdReferenceGeneProduct:60946
_chainChangeLogchain:1-478 added on Fri February 6 2015
_displayNameUniProt:Q9UHM6 OPN4
_timestamp2026-02-20 22:13:33
chainchain:1-478
checksumA8022F5B5AA1198F
commentFUNCTION Photoreceptor that binds cis-retinaldehydes (PubMed:15674244). Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light (By similarity). May be involved in the optokinetic visual tracking response (By similarity). May be involved in the regulation of retinal hyaloid vessel growth and regression (By similarity).INTERACTION Expressed in the retina.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
descriptionrecommendedName: Melanopsin alternativeName: Opsin-4
geneNameOPN4
MOP
identifierQ9UHM6
isSequenceChangedFALSE
keywordAlternative splicing
Biological rhythms
Cell membrane
Cell projection
Chromophore
Disulfide bond
G-protein coupled receptor
Membrane
Photoreceptor protein
Proteomics identification
Receptor
Reference proteome
Retinal protein
Sensory transduction
Transducer
Transmembrane
Transmembrane helix
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
nameOPN4
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8993790] ENSEMBL:ENSG00000122375 OPN4 [Homo sapiens]
secondaryIdentifierOPN4_HUMAN
B7ZLB3
Q14D01
Q2PP22
Q8NGQ9
sequenceLength478
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:8976136] UniProt:Q9UHM6-1 OPN4 [Homo sapiens]
[ReferenceIsoform:8976137] UniProt:Q9UHM6-2 OPN4 [Homo sapiens]
(referenceEntity)[EntityWithAccessionedSequence:391825] OPN4 [photoreceptor disc membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q9UHM6 OPN4 (60946)