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Details on Person UniProt:O94826 TOMM70
| Class:Id | ReferenceGeneProduct:60918 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-608 added on Sat February 7 2015;initiator methionine:1 for 60918 removed on Fri Nov 03 2023;initiator methionine: for 60918 added on Fri Nov 03 2023;initiator methionine: for 60918 removed on Fri Aug 15 2025;initiator methionine:1 for 60918 added on Fri Aug 15 2025 |
| _displayName | UniProt:O94826 TOMM70 |
| _timestamp | 2025-08-15 21:42:15 |
| chain | initiator methionine:1 chain:2-608 |
| checksum | 5AAF5CAAA8582480 |
| comment | FUNCTION Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812).SUBUNIT Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (PubMed:18331822). Interacts with CAPN8 (By similarity). Interacts with TRADD, TRAF6 and STING (PubMed:20628368). Interacts with MAVS; the interaction is enhanced by Sendai virus infection (PubMed:20628368). Interacts with HSPA8 and HSP90AA1; both interactions are required for preprotein mitochondrial import (PubMed:12526792). The interaction with HSP90AA1 is direct and mediates the association of TOMM70 with IRF3 and TBK1 (PubMed:20628368, PubMed:25609812). Upon mitochondrial depolarization, interacts with PINK1; the interaction is required for PINK1-TOM-TIM23 supercomplex formation which is critical for PINK1 stabilization at the outer mitochondrial membrane, kinase activation and downstream mitophagy (PubMed:35391620, PubMed:38416681, PubMed:38848361).SUBUNIT (Microbial infection) Interacts (via C-terminus) with SARS coronaviru/SARS-CoV and SARS coronavirus-2/SARS-CoV-2 virus protein ORF9b.SUBUNIT (Microbial infection) Interacts with parasite T.gondii RH strain MAF1b1; the interaction impairs TOMM70 import activity, enables the parasite to associate with the host mitochondria and facilitates the association of MAF1b1 with MIB complex component SAMM50, promoting the formation of SPOTs (structures positive for outer mitochondrial membrane (OMM)); the interaction is probably indirect.INTERACTION (Microbial infection) During parasite T.gondii-mediated infection, enriched at the interface between the host mitochondria and the parasitopharous vacuole.SIMILARITY Belongs to the Tom70 family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: fullName evidence="15"Mitochondrial import receptor subunit TOM70 alternativeName: Mitochondrial precursor proteins import receptor alternativeName: Translocase of outer membrane 70 kDa subunit alternativeName: fullName evidence="16"Translocase of outer mitochondrial membrane protein 70 |
| geneName | TOMM70 KIAA0719 TOM70 TOMM70A |
| identifier | O94826 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Host-virus interaction Isopeptide bond Membrane Methylation Mitochondrion Mitochondrion outer membrane Phosphoprotein Proteomics identification Reference proteome Repeat TPR repeat Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TOMM70 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991052] ENSEMBL:ENSG00000154174 TOMM70 [Homo sapiens] |
| secondaryIdentifier | TOM70_HUMAN D3DN48 |
| sequenceLength | 608 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1252129] TOMM70 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:6783033] PolyUb-TOMM70A [mitochondrial outer membrane] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:6783126] ubiquitinylated lysine (PolyUb [mitochondrial outer membrane]) at unknown position |
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No pathways have been reviewed or authored by UniProt:O94826 TOMM70 (60918)
