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Details on Person UniProt:Q15388 TOMM20
| Class:Id | ReferenceGeneProduct:60910 |
|---|---|
| _chainChangeLog | chain:1-145 added on Fri February 6 2015 |
| _displayName | UniProt:Q15388 TOMM20 |
| _timestamp | 2026-02-20 23:01:24 |
| chain | chain:1-145 |
| checksum | 5153BD25AC5D9B3A |
| comment | FUNCTION Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). Together with TOMM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (PubMed:18331822). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity).SUBUNIT Part of the translocase of the outer mitochondrial membrane (TOM complex) consisting of at least TOMM5, TOMM6, TOMM7, TOMM20, TOMM22 and TOMM40 (PubMed:18331822, PubMed:40080546). TOMM70 may also be found in the TOM complex (PubMed:18331822). The TOM complex interacts with the VDAC2 homodimer (PubMed:40080546). Upon mitochondrial depolarization, the TOM-VDAC assembly interacts with PINK1; the interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy (PubMed:38416681, PubMed:38848361, PubMed:40080546). Interacts with APEX1 (PubMed:20231292). Interacts with TBC1D21 (By similarity).INTERACTION Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.SIMILARITY Belongs to the Tom20 family. |
| description | recommendedName: Mitochondrial import receptor subunit TOM20 homolog alternativeName: Mitochondrial 20 kDa outer membrane protein alternativeName: Outer mitochondrial membrane receptor Tom20 |
| geneName | TOMM20 KIAA0016 |
| identifier | Q15388 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Isopeptide bond Membrane Mitochondrion Mitochondrion outer membrane Phosphoprotein Protein transport Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | TOMM20 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9005032] ENSEMBL:ENSG00000173726 TOMM20 [Homo sapiens] |
| secondaryIdentifier | TOM20_HUMAN A8K195 Q498B3 Q6IBT4 |
| sequenceLength | 145 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1252091] TOMM20 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:6783144] PolyUb-TOMM20 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:9834948] p-S65-Ub:TOMM20 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:9834976] Ub-TOMM20 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:9843313] K63polyUb-TOMM20 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:9843324] K48polyUb-TOMM20 [mitochondrial outer membrane] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:6783005] ubiquitinylated lysine (PolyUb [mitochondrial outer membrane]) at unknown position [GroupModifiedResidue:9834943] ubiquitinylated lysine (Ub [mitochondrial outer membrane]) at unknown position [GroupModifiedResidue:9834962] ubiquitinylated lysine (p-S65-Ub [mitochondrial outer membrane]) at unknown position [GroupModifiedResidue:9843309] ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position [GroupModifiedResidue:9843325] ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q15388 TOMM20 (60910)
